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. 2023 Jan 11;12(2):594.
doi: 10.3390/jcm12020594.

Older People Hospitalized for COVID-19: Prognostic Role of Multidimensional Prognostic Index and Other Prognostic Scores

Luca Carruba  1 , Maria Armata  1 , Giusy Vassallo  1 , Carlo Saccaro  1 , Carla Di Palermo  1 , Chiara Giannettino  1 , Laura Cilona  1 , Rossella Capitummino  1 , Nicola Veronese  1 , Ligia J Dominguez  1   2 , Mario Barbagallo  1 ; COMEPA Study Authors
Affiliations

Older People Hospitalized for COVID-19: Prognostic Role of Multidimensional Prognostic Index and Other Prognostic Scores

Luca Carruba et al. J Clin Med. .

Abstract

During the SARS-CoV-2 pandemic, frailty and patients’ poor outcomes seem to be closely related. However, there is no clear indication of the significance of this connection and the most adequate risk index in clinical practice. In this study, we compared a short version of MPI (multidimensional prognostic index) and other two prognostic scores for COVID-19 as potential predictors of poor patient outcomes. The patients were consecutively enrolled in the hospital of Palermo for COVID-19. The accuracy of Brief-MPI, 4C score and COVID-GRAM score in points was evaluated using the area under the curve (AUC) with 95% CI, taking mortality or sub-ICU admission as outcome. The study included 112 participants (mean age 77.6, 55.4% males). During a mean of 16 days of hospitalization, Brief-MPI significantly increased by 0.03 ± 0.14 (p = 0.04), whilst COVID-GRAM did not. Brief-MPI, 4C score and COVID-GRAM scores had good accuracy in predicting negative outcomes (AUC > 0.70 for all three scores). Brief-MPI was significantly associated with an increased mortality/ICU admission risk, indicating the importance of multidimensional impairment in clinical decision-making with an accuracy similar to other prognostic scores commonly used in COVID-19 study, providing information regarding domains for which interventions can be proposed.

Keywords: COVID-19; comprehensive geriatric assessment; mortality; multidimensional prognostic index; prognosis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Survival curve by multidimensional prognostic index values.
Figure 2
Figure 2
Accuracy of multidimensional prognostic index, 4C score and COVID-GRAM.
See this image and copyright information in PMC

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