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. 2023 Jan 16;12(2):728.
doi: 10.3390/jcm12020728.

Risk Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North-Eastern Spain: A Case-Control Study

José M Caballero  1   2 , José M Gili  1 , Juan C Pereira  1 , Alba Gomáriz  1 , Carlos Castillo  1 , Montserrat Martín-Baranera  2   3
Affiliations

Risk Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North-Eastern Spain: A Case-Control Study

José M Caballero et al. J Clin Med. .

Abstract

Bladder cancer (BC) is the most common of the malignancies affecting the urinary tract. Smoking and exposure to occupational and environmental carcinogens are responsible for most cases. Vallès Occidental is a highly industrialized area in north-eastern Spain with one of the highest incidences of BC in men. We carried out a case-control study in order to identify the specific risk factors involved in this area. Three hundred and six participants were included (153 cases BC and 153 controls matched for age and sex): in each group, 89.5% (n = 137) were male and the mean age was 71 years (range 30-91; SD = 10.6). There were no differences between groups in family history, body mass index, or dietary habits. Independent risk factors for CV were smoking (OR 2.08; 95% CI 1.30-3.32; p = 0.002), the use of analgesics in nonsmokers (OR 10.00; 95% CI 1.28-78.12; p = 0.028), and profession (OR: 8.63; 95% CI 1.04-71.94; p = 0.046). The consumption of black and blond tobacco, the use of analgesics in nonsmokers, and occupational exposures are risk factors for the development of BC in this area, despite the reduction in smoking in the population and the extensive measures taken in the last few decades in major industries to prevent exposure to occupational carcinogens.

Keywords: analgesics; bladder cancer; occupational exposure; risk factors; smoking.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Babjuk M., Oosterlinck W., Sylvester R., Kaasinen E., Böhle A., Palou-Redorta J., Rouprêt M., European Association of Urology (EAU) EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update. Eur. Urol. 2011;59:997–1008. doi: 10.1016/j.eururo.2011.03.017. - DOI - PubMed
    1. Miñana B., Cózar J.M., Palou J., Urzaiz M.U., Medina-Lopez R.A., Ríos J.S., de la Rosa-Kehrmann F., Chantada-Abal V., Lozano F., Ribal M.J., et al. Bladder cancer in Spain 2011: Population based study. J. Urol. 2014;191:323–328. doi: 10.1016/j.juro.2013.08.049. - DOI - PubMed
    1. Antoni S., Ferlay J., Soerjomataram I., Znaor A., Jemal A., Bray F. Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends. Eur. Urol. 2017;71:96–108. doi: 10.1016/j.eururo.2016.06.010. - DOI - PubMed
    1. Urrutia G., Serra C., Bonfill X., Bastús R., Grupo Trabajo para el Estudio del Cáncer de Vejiga Urinaria en la Comarca del Valles Occidental Incidencia del cáncer de vejiga urinaria en un área industrializada de España [Incidence of urinary bladder cancer in an industrialized area of Spain] Gac. Sanit. 2002;16:291–297. doi: 10.1016/S0213-9111(02)71927-4. - DOI - PubMed
    1. Caballero J.M., Pérez-Márquez M., Gili J.M., Pereira J.C., Gomáriz A., Castillo C., Martin-Baranera M. Environmental Factors Involved in the High Incidence of Bladder Cancer in an Industrialized Area in North-Eastern Spain. J. Environ. Public Health. 2022;2022:1051046. doi: 10.1155/2022/1051046. - DOI - PMC - PubMed