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Review
. 2023 Jan 10;13(1):133.
doi: 10.3390/jpm13010133.

Insights into Personalised Medicine in Bronchiectasis

Affiliations
Review

Insights into Personalised Medicine in Bronchiectasis

Clementine S Fraser et al. J Pers Med. .

Abstract

Bronchiectasis is a heterogenous disease with multiple aetiologies resulting in inflammation and dilatation of the airways with associated mucus production and chronic respiratory infection. The condition is being recognised ever more frequently as the availability of computed tomography increases. It is associated with significant morbidity and healthcare-related costs. With new understanding of the disease process, varying endotypes, identification of underlying causes and treatable traits, the management of bronchiectasis can be increasingly personalised.

Keywords: bronchiectasis; endotypes; personalised medicine; phenotypes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Bronchiectasis diagnostic flowchart.
Figure 2
Figure 2
Computed tomography demonstrating cystic bronchiectasis in a patient with idiopathic bronchiectasis.
Figure 3
Figure 3
Chronic pulmonary aspergillosis in a patient with bronchiectasis mainly involving the upper lobes.

References

    1. Dhar R., Singh S., Talwar D., Mohan M., Tripathi S.K., Swarnakar R., Trivedi S., Rajagopalan S., Dsouza G., Padmanabhan A., et al. Bronchiectasis in India: Results from the European multicentre bronchiectasis audit and research collaboration (EMBARC) and respiratory research network of India registry. Lancet. Glob. Health. 2019;7:1269–1279. doi: 10.1016/S2214-109X(19)30327-4. - DOI - PubMed
    1. Ouedraogo A.R., Sanyu I., Nqwata L., Amare E., Gordon S., Ardrey J., Mortimer K., Meghji J. Knowledge, attitudes, and practice about bronchiectasis among general practitioners in four African cities. J. Pan Afr. Thorac. Soc. 2021;2:94–100. doi: 10.25259/JPATS_5_2021. - DOI
    1. Aksamit T.R., O’Donnell A.E., Barker A., Olivier K.N., Winthrop K.L., Daniels M.L.A., Johnson M.M., Eden E., Griffith D., Knowles M. Adult patients with bronchiectasis: A first look at the US bronchiectasis research registry. Chest. 2017;151:982–992. doi: 10.1016/j.chest.2016.10.055. - DOI - PMC - PubMed
    1. Aliberti S., Sotgiu G., Lapi F., Gramegna A., Cricelli C., Blasi F. Prevalence and incidence of bronchiectasis in Italy. BMC Pulm. Med. 2020;20:15. doi: 10.1186/s12890-020-1050-0. - DOI - PMC - PubMed
    1. Quint J.K., Millett E.R.C., Joshi M., Navaratnam V., Thomas S.L., Hurst J.R., Smeeth L., Brown J.S. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: A population-based cohort study. Eur. Respir. J. 2016;47:186–193. doi: 10.1183/13993003.01033-2015. - DOI - PMC - PubMed

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