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Review
. 2023 Jan 14;13(1):158.
doi: 10.3390/jpm13010158.

Direct Oral Anticoagulants for Stroke and Systemic Embolism Prevention in Patients with Left Ventricular Thrombus

Minerva Codruta Badescu  1   2 , Victorita Sorodoc  1   3 , Catalina Lionte  1   3 , Anca Ouatu  1   2 , Raluca Ecaterina Haliga  1   3 , Alexandru Dan Costache  1   4 , Oana Nicoleta Buliga-Finis  1   2 , Ioan Simon  5 , Laurentiu Sorodoc  1   3 , Irina-Iuliana Costache  1   6 , Ciprian Rezus  1   2
Affiliations
Review

Direct Oral Anticoagulants for Stroke and Systemic Embolism Prevention in Patients with Left Ventricular Thrombus

Minerva Codruta Badescu et al. J Pers Med. .

Abstract

In recent years, direct oral anticoagulants (DOAC) have accumulated evidence of efficacy and safety in various clinical scenarios and are approved for a wide spectrum of indications. Still, they are currently used off-label for left ventricular thrombus owing to a paucity of evidence. For the same reason, there is a lack of guideline indication as well. Our work is based on an exhaustive analysis of the available literature and provides a structured and detailed update on the use of DOACs in patients with left ventricle thrombus. The safety and efficacy of DOACs were analyzed in particular clinical scenarios. As far as we know, this is the first paper that analyzes DOACs in this approach.

Keywords: COVID-19; direct oral anticoagulants; hypertrophic cardiomyopathy; left ventricular thrombus; myocarditis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The main determinants of left intraventricular thrombosis and oral anticoagulant treatment options.
See this image and copyright information in PMC

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