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. 2023 Jan 5;9(1):81.
doi: 10.3390/jof9010081.

COVID-19-Associated Pulmonary Aspergillosis (CAPA) in Northern Greece during 2020-2022: A Comparative Study According to the Main Consensus Criteria and Definitions

Panagiotis Siasios  1 , Kostoula Arvaniti  2 , Evangelia Zachrou  1 , Aikaterini Poulopoulou  1 , Pinelopi Pisanidou  2 , Georgia Vasileiadou  3 , Evangelos Kaimakamis  3 , Athina Georgopoulou  3 , Foteini Renta  4 , Dimitrios Lathyris  4 , Foteini Veroniki  5 , Eleni Geka  5 , Ioanna Soultati  6 , Eleni Argiriadou  6 , Eleni Apostolidou  7 , Pinelopi Amoiridou  7 , Konstantinos Ioannou  7 , Leonidas Kouras  8 , Ioanna Mimitou  8 , Konstantinos Stokkos  8 , Elliniki Flioni  9 , Evangelos Pertsas  9 , Maria Sileli  10 , Christina Iasonidou  10 , Evdokia Sourla  11 , Georgia Pitsiou  11 , Timoleon-Achilleas Vyzantiadis  1
Affiliations

COVID-19-Associated Pulmonary Aspergillosis (CAPA) in Northern Greece during 2020-2022: A Comparative Study According to the Main Consensus Criteria and Definitions

Panagiotis Siasios et al. J Fungi (Basel). .

Abstract

Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) has emerged as an important complication among patients with acute respiratory failure due to SARS-CoV-2 infection. Almost 2.5 years since the start of the COVID-19 pandemic, it continues to raise concerns as an extra factor that contributes to increased mortality, which is mostly because its diagnosis and management remain challenging. The present study utilises the cases of forty-three patients hospitalised between August 2020 and February 2022 whose information was gathered from ten ICUs and special care units based in northern Greece. The main aim was to describe the gained experience in diagnosing CAPA, according to the implementation of the main existing diagnostic consensus criteria and definitions, and present the different classification of the clinical cases due to the alternative algorithms.

Keywords: SARS-CoV-2 pandemic; coronavirus disease 2019-associated pulmonary aspergillosis (CAPA); criteria; definitions; diagnosis; invasive pulmonary aspergillosis; mycology laboratory.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Survival probability curve for the patients admitted in the ICU due to COVID-19 infection.
Figure 2
Figure 2
Kaplan–Meier survival curves for the mortality of patients enrolled, according to their age (log rank test, p = 0.06).
Figure 3
Figure 3
(a) Kaplan–Meier survival curves for the mortality of patients with putative CAPA or colonisation by Aspergillus according to the modified AspICU algorithm (log rank test, p = 0.7); (b) Kaplan–Meier survival curves for the mortality of patients with possible, probable CAPA or Aspergillus colonisation according to the ECMM/ISHAM criteria (log rank test, p = 0.7).
Figure 3
Figure 3
(a) Kaplan–Meier survival curves for the mortality of patients with putative CAPA or colonisation by Aspergillus according to the modified AspICU algorithm (log rank test, p = 0.7); (b) Kaplan–Meier survival curves for the mortality of patients with possible, probable CAPA or Aspergillus colonisation according to the ECMM/ISHAM criteria (log rank test, p = 0.7).
See this image and copyright information in PMC

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