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Review
. 2022 Dec 20;13(1):4.
doi: 10.3390/metabo13010004.

Hemorheological and Microcirculatory Relations of Acute Pancreatitis

Robert Kotan  1 , Katalin Peto  2 , Adam Deak  2 , Zsolt Szentkereszty  3 , Norbert Nemeth  2
Affiliations
Review

Hemorheological and Microcirculatory Relations of Acute Pancreatitis

Robert Kotan et al. Metabolites. .

Abstract

Acute pancreatitis still means a serious challenge in clinical practice. Its pathomechanism is complex and has yet to be fully elucidated. Rheological properties of blood play an important role in tissue perfusion and show non-specific changes in acute pancreatitis. An increase in blood and plasma viscosity, impairment of red blood cell deformability, and enhanced red blood cell aggregation caused by metabolic, inflammatory, free radical-related changes and mechanical stress contribute to the deterioration of the blood flow in the large vessels and also in the microcirculation. Revealing the significance of these changes in acute pancreatitis may better explain the pathogenesis and optimize the therapy. In this review, we give an overview of the role of impaired microcirculation by changes in hemorheological properties in acute pancreatitis.

Keywords: acute pancreatitis; hemorheology; microcirculation; red blood cell aggregation; red blood cell deformability.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic overview of factors and effects causing micro-rheological changes and their consequences on microcirculation.
See this image and copyright information in PMC

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