Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan 5;28(2):516.
doi: 10.3390/molecules28020516.

Combination of Enzymes and Deep Eutectic Solvents as Powerful Toolbox for Organic Synthesis

Davide Arnodo  1 , Elia Maffeis  1 , Francesco Marra  1 , Stefano Nejrotti  1 , Cristina Prandi  1
Affiliations
Review

Combination of Enzymes and Deep Eutectic Solvents as Powerful Toolbox for Organic Synthesis

Davide Arnodo et al. Molecules. .

Abstract

During the last decade, a wide spectrum of applications and advantages in the use of deep eutectic solvents for promoting organic reactions has been well established among the scientific community. Among these synthetic methodologies, in recent years, various examples of biocatalyzed processes have been reported, making use of eutectic mixtures as reaction media, as an improvement in terms of selectivity and sustainability. This review aims to show the newly reported protocols in the field, subdivided by reaction class as a 'toolbox' guide for organic synthesis.

Keywords: asymmetric synthesis; biocatalysis; deep eutectic solvents; sustainable processes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Choi Y.H., van Spronsen J., Dai Y., Verberne M., Hollmann F., Arends I.W., Witkamp G.-J., Verpoorte R. Are natural deep eutectic solvents the missing link in understanding cellular metabolism and physiology? Plant Physiol. 2011;156:1701–1705. doi: 10.1104/pp.111.178426. - DOI - PMC - PubMed
    1. Panić M., Cvjetko Bubalo M., Radojčić Redovniković I. Designing a biocatalytic process involving deep eutectic solvents. J. Chem. Technol. Biotechnol. 2021;96:14–30. doi: 10.1002/jctb.6545. - DOI
    1. Gotor-Fernández V., Paul C.E. Deep eutectic solvents for redox biocatalysis. J. Biotechnol. 2019;293:24–35. doi: 10.1016/j.jbiotec.2018.12.018. - DOI - PubMed
    1. Juneidi I., Hayyan M., Hashim M.A. Intensification of biotransformations using deep eutectic solvents: Overview and outlook. Process Biochem. 2018;66:33–60. doi: 10.1016/j.procbio.2017.12.003. - DOI
    1. Ibn Majdoub Hassani F.Z., Amzazi S., Lavandera I. The versatile applications of DES and their influence on oxidoreductase-mediated transformations. Molecules. 2019;24:2190. doi: 10.3390/molecules24112190. - DOI - PMC - PubMed

LinkOut - more resources