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. 2023 Jan 9;28(2):650.
doi: 10.3390/molecules28020650.

Visible-Light-Enhanced Antibacterial Activity of Silver and Copper Co-Doped Titania Formed on Titanium via Chemical and Thermal Treatments

Kanae Suzuki  1 , Misato Iwatsu  2 , Takayuki Mokudai  3 , Maiko Furuya  2 , Kotone Yokota  2 , Hiroyasu Kanetaka  2 , Masaya Shimabukuro  4 , Taishi Yokoi  4 , Masakazu Kawashita  4
Affiliations

Visible-Light-Enhanced Antibacterial Activity of Silver and Copper Co-Doped Titania Formed on Titanium via Chemical and Thermal Treatments

Kanae Suzuki et al. Molecules. .

Abstract

Dental implants made of titanium (Ti) are used in dentistry, but peri-implantitis is a serious associated problem. Antibacterial and osteoconductive Ti dental implants may decrease the risk of peri-implantitis. In this study, titania (TiO2) co-doped with silver (Ag) at 2.5 at.% and copper (Cu) at 4.9 at.% was formed on Ti substrates via chemical and thermal treatments. The Ag and Cu co-doped TiO2 formed apatite in a simulated body fluid, which suggests osteoconductivity. It also showed antibacterial activity against Escherichia coli, which was enhanced by visible-light irradiation. This enhancement might be caused by the synergistic effect of the release of Ag and Cu and the generation of •OH from the sample. Dental implants with such a Ag and Cu co-doped TiO2 formed on their surface may reduce the risk of peri-implantitis.

Keywords: antibacterial activity; copper; silver; titania; visible-light-responsive photocatalysis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) SEM images and (b) TF-XRD patterns of samples.
Figure 2
Figure 2
(a) Ag 3d and (b) Cu 2p electron energy region spectra of samples.
Figure 3
Figure 3
(a) SEM images and (b) TF-XRD patterns of samples after immersion in SBF for 7 days.
Figure 4
Figure 4
Ag and Cu ion release behavior from samples in PBS. (a) Accumulated-released amounts of Ag or Cu vs. soaking period and (b) accumulated-released amounts of Ag or Cu vs. square root of soaking period.
Figure 5
Figure 5
Number of viable bacteria for samples under conditions with and without visible-light irradiation. Bars with different letters (lowercase a–c for no visible-light irradiation group and uppercase A and B for visible-light irradiation group) are significantly different (p < 0.01). Asterisk (*) represents significant differences (p < 0.01) between no visible-light irradiation and visible-light irradiation.
See this image and copyright information in PMC

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