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. 2023 Jan 14;15(2):440.
doi: 10.3390/nu15020440.

Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

Małgorzata Kaczkan  1 , Sylwia Czaja-Stolc  1 , Małgorzata Szczuko  2 , Arleta Drozd  2 , Przemysław Rutkowski  3 , Alicja Dębska-Ślizień  4 , Sylwia Małgorzewicz  1
Affiliations

Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis

Małgorzata Kaczkan et al. Nutrients. .

Abstract

The concentration of water-soluble vitamins (except folic acid and vitamin B12) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD patients in comparison with healthy subjects and to assess the impact of diabetes mellitus (DM) coexistence on the concentration of these vitamins. The two-center study included 142 HD patients and a control group of 31 healthy subjects. Vitamins concentration was determined using high-performance liquid chromatography (HPLC). Vitamin B1, B6, and B12 levels were significantly lower in the HD group than in the control group (p < 0.001). Vitamin B1 and B2 were negatively correlated with blood urea nitrogen (BUN) levels before HD (R = −0.39, R = −0.38; p < 0.05). Vitamin B3, B12, and C were positively correlated with the albumin concentration (R = 0.26, R = 0.27, R = 0.28; p < 0.05). Among diabetic patients, only the concentration of vitamin B1 was lower than among non-diabetic patients. The concentration of water-soluble vitamins may be related to the adequacy of dialysis, the time of laboratory determination since the last dialysis, diet, coexistence of other diseases, use of drugs, and dietary supplements in individual patients.

Keywords: diabetes mellitus; hemodialysis; water-soluble vitamins.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scheme of the study.
Figure 2
Figure 2
Comparison of blood vitamin levels between HD patients and the control group. *—p < 0.05.
See this image and copyright information in PMC

References

    1. Sabatino A., Regolisti G., Karupaiah T., Sahathevan S., Sadu Singh B.K., Khor B.H., Salhab N., Karavetian M., Cupisti A., Fiaccadori E. Protein-energy wasting and nutritional supplementation in patients with end-stage renal disease on hemodialysis. Clin. Nutr. 2017;36:663–671. doi: 10.1016/j.clnu.2016.06.007. - DOI - PubMed
    1. Clase C.M., Ki V., Holden R.M. Water-soluble vitamins in people with low glomerular filtration rate or on dialysis: A review. Semin. Dial. 2013;26:546–567. doi: 10.1111/sdi.12099. - DOI - PMC - PubMed
    1. Ronco C., Clark W.R. Haemodialysis membranes. Nat. Rev. Nephrol. 2018;14:394–410. doi: 10.1038/s41581-018-0002-x. - DOI - PubMed
    1. Jankowska M., Lichodziejewska-Niemierko M., Rutkowski B., Dębska-Ślizień A., Małgorzewicz S. Water soluble vitamins and peritoneal dialysis—State of the art. Clin. Nutr. 2017;36:1483–1489. doi: 10.1016/j.clnu.2016.12.021. - DOI - PubMed
    1. Lasseur C., Parrot F., Delmas Y., Level C., Ged C., Redonnet-Vernhet I., Montaudon D., Combe C., Chauveau P. Impact of high-flux/high-efficiency dialysis on folate and homocysteine metabolism. J. Nephrol. 2001;14:32–35. - PubMed