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Meta-Analysis
. 2023 Jan 16;15(2):467.
doi: 10.3390/nu15020467.

Does Bariatric Surgery Reduce the Risk of Colorectal Cancer in Individuals with Morbid Obesity? A Systematic Review and Meta-Analysis

Andrea Chierici  1 , Paolo Amoretti  1 , Céline Drai  1   2 , Serena De Fatico  1 , Jérôme Barriere  3 , Luigi Schiavo  4 , Antonio Iannelli  1   2   5
Affiliations
Meta-Analysis

Does Bariatric Surgery Reduce the Risk of Colorectal Cancer in Individuals with Morbid Obesity? A Systematic Review and Meta-Analysis

Andrea Chierici et al. Nutrients. .

Abstract

Bariatric surgery has shown to be effective in producing sustained weight loss and the resolution of obesity related medical problems. Recent research focused on the role of obesity and adipose tissue in tumorigenesis, finding a strong crosslink through different mechanisms and highlighting an increase in cancer incidence in individuals with obesity. The aim of this meta-analysis is to find if bariatric surgery reduces the incidence of colorectal cancer in patients with obesity. We performed a meta-analysis including 18 studies (PROSPERO ID: CRD4202235931). Bariatric surgery was found to be significantly protective toward colorectal cancer incidence in individuals with obesity (HR: 0.81, p = 0.0142). The protective effect persisted when considering women (RR: 0.54, p = 0.0014) and men (RR: 0.74, p = 0.2798) separately, although this was not significant for the latter. No difference was found when comparing Roux-en-Y gastric bypass and sleeve gastrectomy. Bariatric surgery reduces the incidence of colorectal cancer in individuals with obesity independently from gender and surgical procedure. Prospective large cohort studies are needed to confirm these findings.

Keywords: bariatric surgery; colorectal cancer; mortality; risk.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow-chart depicting the overall review process.
Figure 2
Figure 2
Forest plot comparing colorectal cancer incidence in individuals with obesity who did or did not undergo BS [2,6,20,21,22,23,25,26,27,28,29,30,31,32,33,34,35].
Figure 3
Figure 3
Forest plot of HR meta-analysis after sensitivity analysis [6,20,27,30,31,33,34].
Figure 4
Figure 4
Risk of bias barplot with details of risk of bias for each bias domain.
See this image and copyright information in PMC

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