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Review
. 2023 Jan 1;15(1):153.
doi: 10.3390/pharmaceutics15010153.

Biopolymer-Based Nanosystems for siRNA Drug Delivery to Solid Tumors including Breast Cancer

Md Abdus Subhan  1 , Vladimir P Torchilin  2   3
Affiliations
Review

Biopolymer-Based Nanosystems for siRNA Drug Delivery to Solid Tumors including Breast Cancer

Md Abdus Subhan et al. Pharmaceutics. .

Abstract

Nanobiopolymers such as chitosan, gelatin, hyaluronic acid, polyglutamic acid, lipids, peptides, exosomes, etc., delivery systems have prospects to help overwhelmed physiological difficulties allied with the delivery of siRNA drugs to solid tumors, including breast cancer cells. Nanobiopolymers have favorable stimuli-responsive properties and therefore can be utilized to improve siRNA delivery platforms to undruggable MDR metastatic cancer cells. These biopolymeric siRNA drugs can shield drugs from pH degradation, extracellular trafficking, and nontargeted binding sites and are consequently suitable for drug internalization in a controlled-release fashion. In this review, the utilization of numerous biopolymeric compounds such as siRNA drug delivery systems for MDR solid tumors, including breast cancers, will be discussed.

Keywords: biopolymer; breast cancer; drug delivery; siRNA therapy; solid tumors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Biopolymers could be achieved for different sources. Adapted with permission from Ref. [23]. Copyright © 2023 Pathak, Singh, Singh, Sharma, Singh, Gupta, Mishra, Mishra and Tripathi.
Figure 2
Figure 2
(a) Anionic polymers included in siRNA lipoplexes. (b) Different anionic polymers. Adapted with permission from Ref. [21]. Copyright © 2023–2022 John Wiley & Sons, Inc.
Figure 3
Figure 3
GNPs prepared by the supramolecular approach exhibited a gene silencing mechanism with high efficiency and low toxicity. Adapted with permission from Ref. [63]. Copyright © 2023 American Chemical Society.
Figure 4
Figure 4
Post-operation metastatic inhibition in breast tumors through CBSA/siS100A4@Exosome. Adapted with permission from Ref. [99]. Copyright @2022, Goyal, Chopra, singh, Dua and Gautam.
See this image and copyright information in PMC

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