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. 2023 Jan 6;15(2):297.
doi: 10.3390/polym15020297.

Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses

Song-Yi Yang  1 , Myung-Jin Lee  2
Affiliations

Poly (Methyl Methacrylate)-Containing Silver-Phosphate Glass Exhibits Potent Antimicrobial Activity without Deteriorating the Mechanical and Biological Properties of Dental Prostheses

Song-Yi Yang et al. Polymers (Basel). .

Abstract

Poly (methyl methacrylate) (PMMA) is a commonly used denture material with poor antimicrobial effects. This study investigated the antimicrobial effects of PMMA-containing silver-phosphate glass. We fabricated a novel material comprising PMMA-containing silver-phosphate glass. Then, microhardness, flexural strength, and gloss unit were analyzed. Antimicrobial activity against Streptococcus mutans and Candida albicans was investigated. Colony-forming units were counted, and antimicrobial rates were measured. Biocompatibility tests were performed using a colorimetric MTT assay for evaluating cell metabolic activity. The microhardness, flexural strength, and gloss unit of the experimental groups (with silver-phosphate glass) were not significantly different from those of the control group (no silver-phosphate glass) (P > 0.05), which showed clinically valid values. With increasing proportions of silver-phosphate glass, the antimicrobial activity against the two microorganisms increased (P < 0.05). Furthermore, S. mutans showed more than 50% antimicrobial activity in 4%, 6%, and 8% experimental groups, C. albicans showed more than 50% antimicrobial activity in 6% and 8% groups, and a statistically significant difference in antimicrobial activity was observed compared to the control (P < 0.05). The cell viability of the experimental groups was not significantly different from that of the control group (P > 0.05). Both control and experimental groups showed approximately 100% cell viability. These results suggest that silver-phosphate glass is a promising antimicrobial material in dentistry.

Keywords: antimicrobial effect; dental materials; poly (methyl methacrylate); silver-phosphate glass.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Particulate properties of silver-phosphate glass: (A) X-ray diffraction patterns of silver-phosphate glass, (B) particle size distribution, (C) zeta potential distribution.
Figure 2
Figure 2
Representative SEM micrographs of the sample surfaces: (A) control, (B) 2%, (C) 4%, (D) 6%, (E) 8%.
Figure 3
Figure 3
Comparison of Vickers hardness between the samples. “a” indicates that there is no statistically significant difference between the groups (P > 0.05).
Figure 4
Figure 4
Comparison of the flexural strength between the groups. Different letters indicate a statistically significant difference (P < 0.05).
Figure 5
Figure 5
Comparison of surface gloss between the groups. “a” indicates that there is no statistically significant difference (P > 0.05).
Figure 6
Figure 6
Antimicrobial rates of (A) S. mutans and (B) C. albicans. The same letter indicates no statistically significant difference (P > 0.05). Different letters indicate a statistically significant difference (P < 0.05).
Figure 7
Figure 7
(A) Micrographs of L929 cells. (B) Comparison of cell viability of the different groups. “a” indicates no statistically significant difference (P > 0.05).
See this image and copyright information in PMC

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