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. 2023 Jan 12;15(2):407.
doi: 10.3390/polym15020407.

Hybrid Polylactic-Acid-Pectin Aerogels: Synthesis, Structural Properties, and Drug Release

Gabrijela Horvat  1 , Klara Žvab  1 , Željko Knez  1 , Zoran Novak  1
Affiliations

Hybrid Polylactic-Acid-Pectin Aerogels: Synthesis, Structural Properties, and Drug Release

Gabrijela Horvat et al. Polymers (Basel). .

Abstract

Wound-dressing materials often include other materials stimulating wound healing. This research describes the first formulation of biodegradable hybrid aerogels composed of polylactic acid and pectin. The prepared hybrid material showed a highly porous structure with a surface area of 166 ± 22.6 m2·g-1. The addition of polylactic acid may have decreased the surface area of the pure pectin aerogel, but it improved the stability of the material in simulated body fluid (SBF). The pure pectin aerogel showed a high swelling and degradation ratio after 3 h. The addition of the polylactic acid prolonged its stability in the simulated body fluid from 24 h to more than one week, depending on the amount of polylactic acid. Biodegradable aerogels were loaded with indomethacin and diclofenac sodium as model drugs. The entrapment efficiencies were 63.4% and 62.6% for indomethacin and diclofenac sodium, respectively. Dissolution of both drugs was prolonged up to 2 days. Finally, sodium percarbonate and calcium peroxide were incorporated into the bioaerogels as chemical oxygen sources, to evaluate oxygen generation for potential wound healing applications.

Keywords: bioaerogel; hybrid aerogels; pectin; polylactic acid; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
(a) FT-IR spectra of P1:PLA1, P1:PLA2, and PLA samples. (b) Comparison of FT–NIR spectra of the prepared hybrid samples and references, and (c) Comparison of the FT–NIR spectra of hybrid samples loaded with model drugs IND and DCF with the native spectra of pure model drugs.
Figure 1
Figure 1
(a) FT-IR spectra of P1:PLA1, P1:PLA2, and PLA samples. (b) Comparison of FT–NIR spectra of the prepared hybrid samples and references, and (c) Comparison of the FT–NIR spectra of hybrid samples loaded with model drugs IND and DCF with the native spectra of pure model drugs.
Figure 2
Figure 2
SEM images of (a) PLA, (b) Pectin, (c) P1:PLA2, (d) P1:PLA1.
Figure 3
Figure 3
(a) Nitrogen physisorption curves and (b) Average mesopore size of the reference materials (P and PLA) and hybrids (P1:PLA1, P2:PLA1, and P1:PLA2).
Figure 4
Figure 4
(a) TG and (b) DSC of the prepared hybrid and reference materials.
Figure 5
Figure 5
(a) SBF uptake of the reference and hybrid samples, (b) DCF and IND dissolution from the P1:PLA1:DCF and P1:PLA1:IND samples. Each sample was measured in duplicate, and the standard deviation is expressed as error bars.
Figure 6
Figure 6
Oxygen generation from P1:PLA1:O2, measured for 2 days.
See this image and copyright information in PMC

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