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. 2023 Mar:98:104068.
doi: 10.1016/j.etap.2023.104068. Epub 2023 Jan 19.

Combined effect of microplastic, salinomycin and heating on Unio tumidus

Viktoria Martyniuk  1 , Vira Khoma  2 , Tetiana Matskiv  3 , Kateryna Yunko  4 , Lesya Gnatyshyna  5 , Oksana Stoliar  6 , Caterina Faggio  7
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Free article

Combined effect of microplastic, salinomycin and heating on Unio tumidus

Viktoria Martyniuk et al. Environ Toxicol Pharmacol. 2023 Mar.
Free article

Abstract

Microplastic (MP) and heating (T) suspected to modulate biological effects of aquatic contaminants. Salinomycin (Sal) is veterinary antibiotic and anticancer agent. The goal of this study was to examine the multistress effect of MP, Sal and T on the bioindicator bivalve mollusc. The Unio tumidus were treated with MP (1 mg L-1), Sal (0.6 µg L-1), their combination under 18° C (Mix) and 25° C (MixT) for 14 days. The digestive glands were analyzed. MP and Sal did not cause changes of Mn- and Cu,Zn-SOD, lipid peroxidation and Cyp-450-depended EROD levels, whereas catalase, GST and protein carbonyls (Sal-group) increased compared to control. In the Mix-group, enzymes, particularly EROD and GST (by 34% and 115% respectively) were up-regulated. However, in the MixT-group, they were corresponding to control or lesser (EROD, catalase). Our findings emphasize the need to take into account multistress interactions in the MP environmental risk assessment.

Keywords: Biotransformation; Microplastic; Mussel; Oxidative stress; Pharmaceutical; Toxicity.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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