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. 2023 May;86(5):534-536.
doi: 10.1016/j.jinf.2023.01.017. Epub 2023 Jan 18.

A novel near-patient host-protein score predicts COVID-19 deterioration at presentation to secondary care

Rahul Atul Shah  1 , Alexander J Mentzer  2 , Tim James  3 , Stuart Cox  3 , Kevin Paddon  3 , Jordan Bowen  4 , James N Fullerton  5
Affiliations

A novel near-patient host-protein score predicts COVID-19 deterioration at presentation to secondary care

Rahul Atul Shah et al. J Infect. 2023 May.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest This was an investigator-led study and MeMed had no control over the study design, data analysis or interpretation. MeMed reviewed the study design, result and interpretation and made no changes prior to submission. Reagents for MeMed COVID-19 Severity™ measures were provided by MeMed, no financial support was received aside from this. All authors declare no conflicts of interest.

Figures

Fig 1
Fig. 1
Biomarkers to predict the risk of deterioration of patients presenting to ambulatory care and A&E with COVID-19. A) The receiver operating curve (ROC) distributions for two biomarkers and the MeMed COVID-19 Severity™ assay measured in 52 patients with confirmed COVID-19. ROC analyses were undertaken using the pROC package and the comparison of the paired ROC statistics was calculated using DeLong's test. B) The Spearman rank rho correlation between the log10-transformed distributions of the predominant biomarkers associated with deterioration in COVID-19, measured in 52 patients with confirmed COVID-19.
See this image and copyright information in PMC

References

    1. Oved K, Cohen A, Boico O, Navon R, Friedman T, Etshtein L, et al. A novel host-proteome signature for distinguishing between acute bacterial and viral infections. PLoS One. 2015;10(3) - PMC - PubMed
    1. Hainrichson M, Avni N, Eden E, Feigin P, Gelman A, Halabi S, et al. A point-of-need platform for rapid measurement of a host-protein score that differentiates bacterial from viral infection: Analytical evaluation. Clin Biochem. 2022 Apr 26 S0009-9120(22)00115-1. - PubMed
    1. Mastboim NS, Angel A, Shaham O, Ber TI, Navon R, Simon E, et al. 2021. An immune-protein signature combining TRAIL, IP-10 and CRP for accurate prediction of severe COVID-19 outcome. medRxiv doi:10.1101/2021.06.27.21259196. - DOI - PMC - PubMed
    1. Mentzer AJ, James T, Yongya M, Cox S, Paddon K, Shine B, et al. Serum calprotectin is not an independent predictor of severe COVID-19 in ambulatory adult patients. J Infect. 2022 Feb;84(2):e27–e29. - PMC - PubMed
    1. Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC, et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 2011 Mar 17;12:77. - PMC - PubMed