Have we found the missing link between inflammation, fibrosis, and calcification in calcific aortic valve disease?

Marcy Martin¹, Sarah E Motta¹, Maximilian Y Emmert^{1

2

3}

Affiliations

¹ Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland.
² Department of Cardiovascular Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany.
³ Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Augustenburger Platz 1, Berlin D-13353, Germany.

Editorial

Marcy Martin et al. Eur Heart J. 2023.

. 2023 Mar 7;44(10):899-901.

doi: 10.1093/eurheartj/ehac787.

Marcy Martin¹, Sarah E Motta¹, Maximilian Y Emmert^{1

2

3}

¹ Institute for Regenerative Medicine (IREM), University of Zurich, Zurich, Switzerland.
² Department of Cardiovascular Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany.
³ Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Augustenburger Platz 1, Berlin D-13353, Germany.

No abstract available

Conflict of interest statement

Conflict of interest: M.M. and S.E.M. have nothing to disclose. M.Y.E. is a shareholder at LifeMatrix Technologies AG.

Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.
Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E. Iqbal F, et al. Eur Heart J. 2023 Mar 7;44(10):885-898. doi: 10.1093/eurheartj/ehac818. Eur Heart J. 2023. PMID: 36660854 Free PMC article.