Immunosuppressive functions of melanoma cell-derived exosomes in plasma of melanoma patients
- PMID: 36684448
- PMCID: PMC9853022
- DOI: 10.3389/fcell.2022.1080925
Immunosuppressive functions of melanoma cell-derived exosomes in plasma of melanoma patients
Abstract
Tumor-derived exosomes (TEX) are a subset of small extracellular vesicles (sEV) present in all body fluids of patients with cancer. In plasma of patients with metastatic melanoma, numbers of exosomes produced by melanoma cells called MTEX are elevated. To study the role of MTEX in melanoma progression, immunoaffinity-based separation of MTEX from total plasma exosomes was performed. The surface of MTEX was decorated by various checkpoint inhibitory proteins, and upon coincubation with immune recipient cells, MTEX suppressed anti-tumor functions of these cells. MTEX emerge as a major mechanism of immune suppression in melanoma and thus might play a role in promoting melanoma progression.
Keywords: exosomes; immune capture; immune suppression; melanoma; melanoma cell-derived exosomes (MTEX); small extracellular vesicles.
Copyright © 2023 Whiteside.
Conflict of interest statement
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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