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. 2023 Jan 5:28:1610598.
doi: 10.3389/pore.2022.1610598. eCollection 2022.

Predictive role of neostromal CD10 expression in breast cancer patients treated with neoadjuvant chemotherapy

Orsolya Olah  1 , Edit Majlat  1 , Renata Koszo  2 , Zoltan Vereb  3 , Andras Voros  1
Affiliations

Predictive role of neostromal CD10 expression in breast cancer patients treated with neoadjuvant chemotherapy

Orsolya Olah et al. Pathol Oncol Res. .

Abstract

Background: The therapeutic strategy of invasive breast cancer is based on routine histopathological markers (estrogen-, progesterone receptor, HER2, Ki67) routinely evaluated in tumor cells. However, the assessment of cancer stroma could influence therapeutic strategies. Studies have shown that stromal expression of CD10, a zinc-dependent metalloproteinase, is associated with biological aggressiveness of the tumor. In the present retrospective study, we aimed to evaluate stromal CD10 expression and association between CD10 expression and response to neoadjuvant chemotherapy in invasive breast cancer. Methods: CD10 immunohistochemistry was performed on core biopsies taken before the neoadjuvant therapy. Stromal CD10 expression was determined and compared with well-known predictive and prognostic tissue markers as well as with the following groups defined according to the degree of tumor response: no regression, partial regression, and complete regression. Results: A total of 60 locally advanced invasive breast carcinomas of "no special type" were included. The proportion of CD10 positive tumors was significantly higher in the "no regression" group compared to "complete regression" group (p = 0.000). Stromal CD10 expression was found to be significantly associated with decrease in response to neoadjuvant chemotherapy. According to CD10 expression we did not find any difference in hormone receptor status, Ki67, tumor grade or neostromal area. Conclusion: Our data suggest that CD10 expression can serve as a predictive marker of the effect of neoadjuvant chemotherapy in breast cancer patients. Therefore, its inclusion into the routine assessment of biopsies to tailor tumor-specific therapeutic strategies merits consideration.

Keywords: CD10; advanced breast cancer; neoadjuvant therapy; neostroma; predictive factors.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Intensive CD10 expression of stromal cells representing the whole stromal area (CD10 immunohistochemistry, 10X).
FIGURE 2
FIGURE 2
Distribution of ER (A), PR (C), Ki67 (B) and tumor size (D) among cases and groups.
FIGURE 3
FIGURE 3
(A) Distribution of CD10 positive and negative cases in groups. The white columns are indicating positive (>10% stromal CD10 immunolabeling) cases. The number of CD10 positive cases was significantly higher in the non-responding group to neoadjuvant chemotherapy (p = 0.006). (B) Quantitative evaluation of CD10 expression showed significant differences among distinct groups similarly to qualitative data.
FIGURE 4
FIGURE 4
Distribution of neostromal area in proportion of the total tumor area among groups.
See this image and copyright information in PMC

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