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Review
. 2023 Jan 4:13:1077419.
doi: 10.3389/fgene.2022.1077419. eCollection 2022.

Biological characteristics of γδT cells and application in tumor immunotherapy

Renhong Zhu  1   2 , Qian Yan  3 , Yashu Wang  4 , Keqiang Wang  1
Affiliations
Review

Biological characteristics of γδT cells and application in tumor immunotherapy

Renhong Zhu et al. Front Genet. .

Abstract

Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex (MHC)-restricted immune response. They play an important role in the body's anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human γδT cells, genetic characteristics, classification, recognition and role of antigens, and research progress in tumor immunotherapy.

Keywords: biological; immunotherapy; progress; tumor; γδT cells.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The tumor-promoting effect of γδT cells.
FIGURE 2
FIGURE 2
Anti-tumor effect of γδT cells.
See this image and copyright information in PMC

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