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Review
. 2023 Jan 5:13:1035910.
doi: 10.3389/fgene.2022.1035910. eCollection 2022.

Survival association of XRCC1 for patients with head and neck squamous cell carcinoma: A systematic review and meta-analysis

Fan Yang  1 , Liuqing Zhou  1 , Jingcai Chen  1 , Yao Luo  1 , Yanjun Wang  1
Affiliations
Review

Survival association of XRCC1 for patients with head and neck squamous cell carcinoma: A systematic review and meta-analysis

Fan Yang et al. Front Genet. .

Abstract

Background: Epidemiologic studies have demonstrated that X-ray repair cross-complementary group 1 (XRCC1) is one of the susceptibility factors in head and neck squamous cell carcinoma (HNSCC) patients. However, its clinical prognostic impact remains controversial. Thus, a meta-analysis was performed to clarify the association between XRCC1 and the survival outcomes in HNSCC patients. Methods: Following the Preferred Reporting Items or Systematic Reviews Meta Analyses (PRISMA) 2020 guidelines, literature searches were systematically performed in PubMed, EMBASE, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases with manual retrieval. Hazard ratios (HRs) and 95% confidence intervals (CIs) were collected to estimate the correlation between XRCC1 and the survival outcomes of HNSCC patients. Results: Ten studies including 1995 HNSCC patients who satisfied the inclusion and exclusion criteria were included in this meta-analysis. Pooled analysis indicated that XRCC1 Arg399Gln and XRCC1 high protein expression were significantly correlated with poor overall survival with HR of 1.31 (95% CIs: 1.03-1.66, p = 0.027) and 2.32 (95% CIs: 1.55-3.48 p = 0.000) in HNSCC patients. In addition, our results demonstrated that XRCC1 was significantly associated with poor progression-free survival (HR = 1.42, 95% CIs: 1.15-1.75, p = 0.001) in HNSCC patients. ConclusionThis meta-analysis demonstrated that XRCC1 Arg399Gln and XRCC1 high protein expression increase the risk of poor survival for HNSCC patients. XRCC1 is a potential therapeutic target for HNSCC.

Keywords: X-ray repair cross-complementing 1; head and neck squamous cell carcinomas; meta-analysis; polymorphism; survival.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flow diagram of the selection of relevant studies included in the meta-analysis. CNKI, Chinese National Knowledge Infrastructure; XRCC1, X-ray repair cross-complementary group 1; HNSCC, head and neck squamous cell carcinoma; HR, hazard ratios.
FIGURE 2
FIGURE 2
Forest plot indicating the overall survival association between XRCC1 gene polymorphisms (Arg194Trp and Arg399Gln)/high XRCC1 protein expression and HNSCC.
FIGURE 3
FIGURE 3
Forest plot indicating the association between XRCC1 and progression-free survival in HNSCC.
FIGURE 4
FIGURE 4
The sensitivity analysis was conducted to evaluate the effects of each single study on the overall effect.
FIGURE 5
FIGURE 5
Publication bias and trim and fill analysis of the enrolled analysis: (A). The Begg’s funnel plot; (B). The Egger’s test. (C). Trim and fill analysis.
See this image and copyright information in PMC

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