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. 2022 Dec 20;14(12):e32733.
doi: 10.7759/cureus.32733. eCollection 2022 Dec.

The Effect of Bariatric Surgery on the Relation Between Retinol-Binding Protein 4 (RBP4) and Vitamin D Plasma Levels in Male Obese Population

Essa J Faqihi  1 , Khalid Alregaiey  1 , Mohammed A Altuwayjiri  1 , Mohammad N Alamri  1 , Bader A Alshehri  1 , Muhammad Iqbal  1
Affiliations

The Effect of Bariatric Surgery on the Relation Between Retinol-Binding Protein 4 (RBP4) and Vitamin D Plasma Levels in Male Obese Population

Essa J Faqihi et al. Cureus. .

Abstract

Objectives Obesity is viewed as a risk factor for several life-threatening diseases. Bariatric surgeries are regarded as a safe and effective way of treating morbid obesity and are associated with alterations in molecules such as Vitamin D and retinol-binding protein 4 (RBP4). The aim of this study was to examine an association between Vitamin D and RBP4 in healthy obese individuals undergoing gastric sleeve surgery. Methods In this observational retrospective cohort study, we used clinical and biochemical profiles of morbidly obese healthy male subjects (BMI > 38.3) who underwent laparoscopic sleeve gastrectomy. RBP4 levels were evaluated by ELISA before and 6-12 months after surgery. Data were analysed using SPSS 23 statistical software. Results RBP4/Vitamin D ratio was reduced significantly after surgery (p < 0.001), however, there was no correlation between Vitamin D and RBP4 (p = 0.353). BMI was reduced significantly after surgery (p < 0.001) but was not correlated with RBP4 or Vitamin D levels before and after surgery (p > 0.05). A significant increase in the levels of calcium post-surgery was observed (p< 0.001). Conclusions In conclusion, plasma levels of Vitamin D were not correlated with RBP4 before or after laparoscopic gastric sleeve surgery.

Keywords: bariatric surgery; obesity; retinol-binding protein 4 (rbp4); saudi arabia; vitamin d.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Correlation between plasma levels of RBP4 and Vitamin D before surgery (n = 33).
RBP4: retinol-binding protein 4
Figure 2
Figure 2. Correlation between plasma levels of RBP4 and Vitamin D after surgery (n = 33).
RBP4: retinol-binding protein 4
See this image and copyright information in PMC

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