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. 2023 Jan 4:12:1071860.
doi: 10.3389/fonc.2022.1071860. eCollection 2022.

Hepatic arterial infusion chemotherapy in hepatocellular carcinoma: A bibliometric and knowledge-map analysis

Mei Li  1   2   3 , Kai Zhang  1   2   3 , Ji'an He  1   2   3 , Weihao Zhang  1   2   3 , Tianye Lv  1   2   3 , Li Wang  1   2   3 , Wenge Xing  1   2   3 , Haipeng Yu  1   2   3
Affiliations

Hepatic arterial infusion chemotherapy in hepatocellular carcinoma: A bibliometric and knowledge-map analysis

Mei Li et al. Front Oncol. .

Abstract

Background: In recent years, hepatic arterial infusion chemotherapy (HAIC) has gained popularity in the treatment of hepatocellular carcinoma. Although several studies have been published, no bibliometric analysis have been conducted on this topic.

Objectives: To understand the development status and future trends in the application of HAIC, we conducted bibliometric analysis to examine the cooperation and influence among countries, institutions, authors, and journals.

Methods: All relevant articles and reviews on the use of HAIC in HCC treatment were retrieved from the Web of Science database. A bibliometric analysis of countries, institutions, journals, authors, and keywords related to this field was performed using R and VOSviewer software. The main aspects analyzed were the research status and key fields of HAIC in HCC treatment.

Results: A total of 1026 articles published in 292 journals by 4937 authors from 959 institutions between 1974 and 2021 were retrieved. A rapid increase in articles published after 1990 was observed, which reached the peak in 2021. Japan had the most publications and citations. Yonsei University, Sun Yat-sen University, and Hiroshima University were the three leading institutions in research on this topic. Kwang-Hyub Han and Masatoshi Kudo have the greatest academic influence in this field. Most publications were made in the Hepato-Gastroenterology, whereas cancer had the most citations. The main aspects of HAIC treatment of HCC include HAIC and TACE, chemotherapy drug selection, HAIC and targeted therapy and immunotherapy, HAIC and surgery, and hepatotoxicity. Keywords such as FOLFOX, lenvatinib, hepatic arterial infusion chemotherapy are hot words in this field in recent years.

Conclusion: The research on the use of HAIC in the treatment of HCC has been on the rise. Currently, HAIC combined with targeted therapy or immunotherapy has attracted significant attention.

Keywords: FOLFOX; bibliometric; data mining; hepatic arterial infusion chemotherapy; hepatocellular carcinoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) A line chart of the number of publications published each year, 1973-2021, as detailed in Supplementary Figure S3 . (B) A line chart showing the average number of citations per article per year. Specific data are in the Supplementary Material Figure S3 .
Figure 2
Figure 2
(A) This is a collaboration network diagram between countries. The color of the nodes represents clustering and the size of the nodes represents centrality and lines between nodes represent the strength of collaborations. (B) This is the collaboration network diagram between organizations. The color of nodes represents clustering and the size of nodes represents centrality and lines between nodes represent the strength of collaborations.
Figure 3
Figure 3
This graph represents top-authors’ production over time, and the node size represents total number of articles. The color of the nodes represents the yearly average number of times each document has been cited.
Figure 4
Figure 4
(A) This is a keyword co-occurrence analysis cluster map. Each color represents a cluster. (B) The graph shows the change over time of the most frequent keywords in each year, with the size of the blue nodes representing the frequency of keyword occurrences. A maximum of 5 keywords are displayed per year.The whole picture is in Supplementary Material Figure S4 .
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