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Case Reports
. 2023 Jan 6;11(1):201-209.
doi: 10.12998/wjcc.v11.i1.201.

Extraskeletal Ewing sarcoma of the stomach: A rare case report

Qiang Shu  1 , Jia-Nong Luo  1 , Xiao-Ling Liu  2 , Min Jing  3 , Ting-Gang Mou  1 , Fei Xie  4
Affiliations
Case Reports

Extraskeletal Ewing sarcoma of the stomach: A rare case report

Qiang Shu et al. World J Clin Cases. .

Abstract

Background: Extraskeletal Ewing sarcoma (EES) is a rare and highly malignant small round cell tumor associated with a poor clinical outcome. Ewing sarcoma (ES) involving the stomach is an uncommon presentation and can be easily confused with other small round cell tumors. We herein present a rare case of ES involving the gastric area.

Case summary: We report a case of gastric ES in a 19-year-old female patient who initially presented with a complaint of a tender epigastric mass for 5 d. Contrast-enhanced abdominal computed tomography revealed a soft-tissue-density mass with a diameter of 8.5 cm between the liver and stomach; the mass was connected to the gastric antrum. Then, the mass was surgically excised completely. Upon histopathological, immunophenotype and molecular analysis, the mass was identified to be a primary gastric ES.

Conclusion: EES is an aggressive tumor with poor prognosis. Therefore, early diagnosis and timely intervention are essential for a good prognosis. It is imperative for us to raise awareness about this rare tumor. Surgical resection is still the best treatment option.

Keywords: CD99; Case report; Ewing’s sarcoma; Extraskeletal; FLI-1; Stomach neoplasms.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Abdominal contrast-enhanced ultrasound. A: Hepatic arterial phase; B: Hepatic portal vein phase; C: Hepatic delay phase.
Figure 2
Figure 2
Contrast-enhanced abdominal computerized tomography. A: Hepatic arterial phase; B: Hepatic portal phase; C: Hepatic venous phase.
Figure 3
Figure 3
Esophagogastroduodenoscopy revealed that the gastric antrum mucosa was intact and smooth.
Figure 4
Figure 4
Postoperative pathological examination. A: Hematoxylin and eosin staining. The tumor was identified to originate from the serous layer of the stomach and involve the muscularis externa of the stomach (20 ×). Upper right inset indicates small round cells with different sizes (original magnification, 200 ×); B-F: CD99-positive, vimentin-positive, FLI-1-positive, NSE-positive, amd SYN-positive cells (immunohistochemistry staining, 200 ×).
Figure 5
Figure 5
Contrast-enhanced abdominal computerized tomography 11 mo postoperatively.
See this image and copyright information in PMC

References

    1. Ye Y, Qiu X, Mei J, He D, Zou A. Primary gastric Ewing sarcoma/primitive neuroectodermal tumor. J Int Med Res. 2021;49:300060520986681. - PMC - PubMed
    1. Lewis TB, Coffin CM, Bernard PS. Differentiating Ewing's sarcoma from other round blue cell tumors using a RT-PCR translocation panel on formalin-fixed paraffin-embedded tissues. Mod Pathol. 2007;20:397–404. - PubMed
    1. Brasme JF, Chalumeau M, Oberlin O, Valteau-Couanet D, Gaspar N. Time to diagnosis of Ewing tumors in children and adolescents is not associated with metastasis or survival: a prospective multicenter study of 436 patients. J Clin Oncol. 2014;32:1935–1940. - PubMed
    1. Hopp AC, Nguyen BD. Gastrointestinal: Multi-modality imaging of extraskeletal Ewing sarcoma of the stomach. J Gastroenterol Hepatol. 2019;34:1273. - PubMed
    1. Huh J, Kim KW, Park SJ, Kim HJ, Lee JS, Ha HK, Tirumani SH, Ramaiya NH. Imaging Features of Primary Tumors and Metastatic Patterns of the Extraskeletal Ewing Sarcoma Family of Tumors in Adults: A 17-Year Experience at a Single Institution. Korean J Radiol. 2015;16:783–790. - PMC - PubMed

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