Construction and Application of DNAzyme-based Nanodevices

doi:10.1007/s40242-023-2334-8

Review

. 2023;39(1):42-60.

doi: 10.1007/s40242-023-2334-8. Epub 2023 Jan 16.

Construction and Application of DNAzyme-based Nanodevices

Bo Wang^#¹, Menghui Wang^#¹, Fangqi Peng^#¹, Xiaoyi Fu², Mei Wen¹, Yuyan Shi¹, Mei Chen³, Guoliang Ke¹, Xiao-Bing Zhang¹

Affiliations

¹ State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 P. R. China.
² Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, 310022 P. R. China.
³ College of Materials Science and Engineering, Hunan University, Changsha, 410082 P. R. China.

^# Contributed equally.

PMID: 36687211
PMCID: PMC9841151
DOI: 10.1007/s40242-023-2334-8

Review

Construction and Application of DNAzyme-based Nanodevices

Bo Wang et al. Chem Res Chin Univ. 2023.

. 2023;39(1):42-60.

doi: 10.1007/s40242-023-2334-8. Epub 2023 Jan 16.

Authors

Bo Wang^#¹, Menghui Wang^#¹, Fangqi Peng^#¹, Xiaoyi Fu², Mei Wen¹, Yuyan Shi¹, Mei Chen³, Guoliang Ke¹, Xiao-Bing Zhang¹

Affiliations

¹ State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082 P. R. China.
² Institute of Basic Medicine and Cancer(IBMC), Chinese Academy of Sciences, Hangzhou, 310022 P. R. China.
³ College of Materials Science and Engineering, Hunan University, Changsha, 410082 P. R. China.

^# Contributed equally.

PMID: 36687211
PMCID: PMC9841151
DOI: 10.1007/s40242-023-2334-8

Abstract

The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing, drug delivery, and so on. DNAzymes are a class of DNA molecules with the specific catalytic activity. Owing to their unique catalytic activity and easy design and synthesis, the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years. In this review, the classification and properties of DNAzyme are first introduced. The construction of several common kinds of DNAzyme-based nanodevices, such as DNA motors, signal amplifiers, and logic gates, is then systematically summarized. We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields. In addition, current limitations and future directions are discussed.

Keywords: Biosensor; DNAzyme; Nanodevice; Therapy.

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Conflict of interest statement

The authors declare no conflicts of interest.

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[1] Di Z, Zhao J, Chu H, Xue W, Zhao Y, Li L. Adv. Mater. 2019;31:e1901885. doi: 10.1002/adma.201901885. - DOI - PubMed

[2] Di Z, Zhao J, Chu H, Xue W, Zhao Y, Li L. Adv. Mater. 2019;31:e1901885. doi: 10.1002/adma.201901885. - DOI - PubMed

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[9] Molden T A, Niccum C T, Kolpashchikov D M. Angew. Chem. Int. Ed. 2020;59:21190. doi: 10.1002/anie.202006384. - DOI - PubMed

[10] Molden T A, Niccum C T, Kolpashchikov D M. Angew. Chem. Int. Ed. 2020;59:21190. doi: 10.1002/anie.202006384. - DOI - PubMed

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Construction and Application of DNAzyme-based Nanodevices

Affiliations

Construction and Application of DNAzyme-based Nanodevices

Authors

Affiliations

Abstract

Conflict of interest statement

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