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Review
. 2023;39(1):42-60.
doi: 10.1007/s40242-023-2334-8. Epub 2023 Jan 16.

Construction and Application of DNAzyme-based Nanodevices

Bo Wang #  1 , Menghui Wang #  1 , Fangqi Peng #  1 , Xiaoyi Fu  2 , Mei Wen  1 , Yuyan Shi  1 , Mei Chen  3 , Guoliang Ke  1 , Xiao-Bing Zhang  1
Affiliations
Review

Construction and Application of DNAzyme-based Nanodevices

Bo Wang et al. Chem Res Chin Univ. 2023.

Abstract

The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing, drug delivery, and so on. DNAzymes are a class of DNA molecules with the specific catalytic activity. Owing to their unique catalytic activity and easy design and synthesis, the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years. In this review, the classification and properties of DNAzyme are first introduced. The construction of several common kinds of DNAzyme-based nanodevices, such as DNA motors, signal amplifiers, and logic gates, is then systematically summarized. We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields. In addition, current limitations and future directions are discussed.

Keywords: Biosensor; DNAzyme; Nanodevice; Therapy.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Di Z, Zhao J, Chu H, Xue W, Zhao Y, Li L. Adv. Mater. 2019;31:e1901885. doi: 10.1002/adma.201901885. - DOI - PubMed
    1. Shi H, Wang Y, Zheng J, Ning L, Huang Y, Sheng A, Chen T, Xiang Y, Zhu X, Li G. ACS Nano. 2019;13:12840. doi: 10.1021/acsnano.9b05082. - DOI - PubMed
    1. Wang X, Kim G, Chu J L, Song T, Yang Z, Guo W, Shao X, Oelze M L, Li K C, Lu Y. J. Am. Chem. Soc. 2022;144:5812. doi: 10.1021/jacs.1c11543. - DOI - PMC - PubMed
    1. Wang Z, Song L, Liu Q, Tian R, Shang Y, Liu F, Liu S, Zhao S, Han Z, Sun J, Jiang Q, Ding B. Angew. Chem. Int. Ed. 2021;60:2594. doi: 10.1002/anie.202009842. - DOI - PubMed
    1. Molden T A, Niccum C T, Kolpashchikov D M. Angew. Chem. Int. Ed. 2020;59:21190. doi: 10.1002/anie.202006384. - DOI - PubMed

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