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Review
. 2022 Dec;13(4):681-690.
doi: 10.1007/s13193-022-01550-6. Epub 2022 May 10.

Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review

Nader Salari  1 , Farahnaz Faraji  2 , Sima Jafarpour  3 , Fatemeh Faraji  4 , Shna Rasoulpoor  5 , Sadat Dokaneheifard  6 , Masoud Mohammadi  7
Affiliations
Review

Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review

Nader Salari et al. Indian J Surg Oncol. 2022 Dec.

Abstract

Chrysin is a natural bioactive compound that is extracted from many trees, honey, and propolis. Chrysin has several pharmacological activities such as anti-inflammatory, anti-cancer, and antioxidant properties. This study was performed to evaluate the anti-cancer activities of chrysin in cancer therapy. The present study was conducted by systematic review of studies published up to August 2021. Related studies were identified by searching Web of Science (WoS), PubMed, Science Direct, SID, MagIran, Scopus, and Google Scholar databases. The keywords of chrysin, cancer, anti-cancer, and cancer therapy were used for searching. The quality of the studies was assessed by the CONSORT checklist. A total of 21 studies were identified. The results of studies showed that chrysin has an anticancer effect by stimulating apoptosis in a wide range of human cells and rats. Chrysin is also an important factor in inhibiting tumor growth and neoplasticity. Chrysin inhibits the growth and proliferation of cancer cells by inducing cytotoxic effects. Therefore, due to the antitumor effects of chrysin and its safety and non-toxicity towards normal cells, this compound can be considered as an adjuvant along with chemotherapeutic agents in cancer treatment.

Keywords: A systematic review; Anti-cancer; Cancer therapy; Chrysin.

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Conflict of interest statement

Competing InterestsThe authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic of chrysin sources and its health claims
Fig. 2
Fig. 2
Flow chart indicating the stages of article selection in this systematic review and meta-analysis (PRISMA 2009)
See this image and copyright information in PMC

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