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Review
. 2023 Jan 6:9:1076210.
doi: 10.3389/fmed.2022.1076210. eCollection 2022.

Astatine-211 based radionuclide therapy: Current clinical trial landscape

Per Albertsson  1   2 , Tom Bäck  3 , Karin Bergmark  1   2 , Andreas Hallqvist  1   2 , Mia Johansson  1   2 , Emma Aneheim  1   3 , Sture Lindegren  3 , Chiara Timperanza  3 , Knut Smerud  4 , Stig Palm  3
Affiliations
Review

Astatine-211 based radionuclide therapy: Current clinical trial landscape

Per Albertsson et al. Front Med (Lausanne). .

Abstract

Astatine-211 (211At) has physical properties that make it one of the top candidates for use as a radiation source for alpha particle-based radionuclide therapy, also referred to as targeted alpha therapy (TAT). Here, we summarize the main results of the completed clinical trials, further describe ongoing trials, and discuss future prospects.

Keywords: alpha particle; astatine-211; clinical trial; human; radionuclide; targeted alpha therapy.

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Conflict of interest statement

PA, TB, KS, SP, EA, and SL are co-founders of Aprit Biotech AB. EA and SL are the co-founders of Atley Solutions AB. KS is the founder of Smerud Medical Research Group. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Corson DR, MacKenzie KR, Segrè E. Possible production of radioactive isotopes of element 85. Phys Rev. (1940) 57:459. 10.1103/PhysRev.57.459 - DOI
    1. Hamilton JG, Durbin PW, Parrott MW. Accumulation of astatine211 by thyroid gland in man. Proc Soc Exp Biol Med. (1954) 86:366–9. 10.3181/00379727-86-21100 - DOI - PubMed
    1. Feng Y, Zalutsky MR. Production, purification and availability of (211)At: near term steps towards global access. Nucl Med Biol. (2021) 100:12–23. 10.1016/j.nucmedbio.2021.05.007 - DOI - PMC - PubMed
    1. Lindegren S, Albertsson P, Back T, Jensen H, Palm S, Aneheim E. Realizing clinical trials with astatine-211: the chemistry infrastructure. Cancer Biother Radiopharm. (2020) 35:425–36. 10.1089/cbr.2019.3055 - DOI - PMC - PubMed
    1. Guérard F, Maingueneau C, Liu L, Eychenne R, Gestin J-F, Montavon G, et al. . Advances in the chemistry of astatine and implications for the development of radiopharmaceuticals. Acc Chem Res. (2021) 54:3264–75. 10.1021/acs.accounts.1c00327 - DOI - PubMed

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