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. 2023 Jan 6:9:1040133.
doi: 10.3389/fmed.2022.1040133. eCollection 2022.

CARE-NS, a research strategy for neurosyphilis

Fang-Zhi Du  1 , Xu Zhang  1 , Rui-Li Zhang  2 , Qian-Qiu Wang  1
Affiliations

CARE-NS, a research strategy for neurosyphilis

Fang-Zhi Du et al. Front Med (Lausanne). .

Abstract

Neurosyphilis is a major clinical manifestation of syphilis. In recent years, an increase in neurosyphilis cases has been reported in many countries. The overall incidence of neurosyphilis remains unknown, and there is a lack of understanding of the disease pathogenesis, which hampers clinical management, development of prevention strategies, and control. This article proposes the CARE-NS research strategy to enhance the clinical management of neurosyphilis, which consists of six key features: comprehensive management including multidisciplinary treatment (C), alleviating neurological impairment and sequelae (A), risk factors and clinical epidemiology (R), etiology and pathogenesis (E), new diagnostic indicators and strategies (N), and social impact and cost-effectiveness analysis (S).

Keywords: CARE-NS strategy; clinical management; epidemiology; neurosyphilis; prevention and control.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Ropper A. Neurosyphilis. N Engl J Med. (2019) 381:1358–63. 10.1056/NEJMra1906228 - DOI - PubMed
    1. de Voux A, Kidd S, Torrone E. Reported cases of neurosyphilis among early syphilis cases–United States, 2009 to 2015. Sex Transm Dis. (2018) 45:39–41. 10.1097/OLQ.0000000000000687 - DOI - PMC - PubMed
    1. Ramachandran P, Baird R, Markey P, Singleton S, Lowe M, Currie B, et al. Neurosyphilis: still prevalent and overlooked in an at risk population. PLoS One. (2020) 15:e0238617. 10.1371/journal.pone.0238617 - DOI - PMC - PubMed
    1. Quintero-Moreno J, Valencia-Vasquez A, Aguirre-Castaneda C. Clinical and socio-demographic profile of neurosyphilis: a retrospective study in a reference centre in Colombia. Rev Neurol. (2019) 69:53–8. 10.33588/rn.6902.2018381 - DOI - PubMed
    1. Daey Ouwens I, Koedijk F, Fiolet A, van Veen M, van den Wijngaard K, Verhoeven W, et al. Neurosyphilis in the mixed urban-rural community of the Netherlands. Acta Neuropsychiatr. (2014) 26:186–92. 10.1017/neu.2013.53 - DOI - PubMed