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. 2023 Mar 20;62(13):e202300172.
doi: 10.1002/anie.202300172. Epub 2023 Feb 6.

Record Ultralarge-Pores, Low Density Three-Dimensional Covalent Organic Framework for Controlled Drug Delivery

Yu Zhao  1   2 , Saikat Das  3 , Taishu Sekine  3 , Haruna Mabuchi  3 , Tsukasa Irie  3 , Jin Sakai  3 , Dan Wen  1   2 , Weidong Zhu  1   2 , Teng Ben  1   2 , Yuichi Negishi  3
Affiliations

Record Ultralarge-Pores, Low Density Three-Dimensional Covalent Organic Framework for Controlled Drug Delivery

Yu Zhao et al. Angew Chem Int Ed Engl. .

Abstract

The unique structural characteristics of three-dimensional (3D) covalent organic frameworks (COFs) like high surface areas, interconnected pore system and readily accessible active sites render them promising platforms for a wide set of functional applications. Albeit promising, the reticular construction of 3D COFs with large pores is a very demanding task owing to the formation of interpenetrated frameworks. Herein we report the designed synthesis of a 3D non-interpenetrated stp net COF, namely TUS-64, with the largest pore size of all 3D COFs (47 Å) and record-low density (0.106 g cm-3 ) by reticulating a 6-connected triptycene-based linker with a 4-connected porphyrin-based linker. Characterized with a highly interconnected mesoporous scaffold and good stability, TUS-64 shows efficient drug loading and controlled release for five different drugs in simulated body fluid environment, demonstrating the competency of TUS-64 as drug nanocarriers.

Keywords: Covalent Organic Framework; Drug Delivery; Mesoporous; Non-Interpenetrated; Three-Dimensional.

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