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. 2023 Dec;45(1):2161395.
doi: 10.1080/0886022X.2022.2161395.

Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study

Vinant Bhargava  1 , Priti Meena  2 , Anil Kumar Bhalla  1 , Devinder Singh Rana  1 , Ashwani Gupta  1 , Manish Malik  1 , Anurag Gupta  1 , Vaibhav Tiwari  1
Affiliations

Prevalence, risk, and outcomes of venous thromboembolic events in kidney transplant recipients: a nested case-control study

Vinant Bhargava et al. Ren Fail. 2023 Dec.

Abstract

Introduction: Thromboembolism is more common in kidney transplant recipients (KTRs) than in the general population. Studies evaluating arterial and venous thromboembolism (VTE) in KTRs are scarce and the magnitude and risk factors are mostly undefined.

Methods: A nested control study was conducted from January 1, 2007, to December 31, 2019. Adult KTRs who were detected to have VTE events during this period were included. The primary outcome was to assess the prevalence of VTE in this population. Secondary outcomes were the assessment of the time to occurrence of the thromboembolic events after transplantation and assessing the risk factors and patient survival. For each subject studied, 4 controls were matched from the data set.

Results: Amongst 2158 patients, 97 (4.5%) were found to have VTE. The median follow-up time was 3.9 years (6-156 months). A total of 101 VTE events were recorded. The most common site of VTE was the lower limb deep vein thrombosis in 79 patients (0.03%)).In multivariate Cox regression analysis, serum creatinine of more than 3 mg/dl [HR 1.30, 95% CI (1.03-1.38)] was independently associated with increased VTE risk. Patients who developed a VTE had higher mortality as compared to patients who did not develop VTE. No increased risk of graft failure was found in VTE patients.

Conclusion: This study suggests that kidney transplantation surgery is a moderate risk factor for VTE, and VTE is associated with higher morbidity and mortality. However, prospective studies are needed to establish a definite role of VTE in outcomes in KTRs.

Keywords: Chemoprophylaxis; deep vein thrombosis; kidney transplant recipient; venous thromboembolic events.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Kaplan-Meier plot showing cumulative VTE occurrences with time.
Figure 2.
Figure 2.
Kaplan-Meier plots showing cumulative survival rates in two study groups.
Figure 3.
Figure 3.
Graphical representation of the study.
See this image and copyright information in PMC

References

    1. Hariharan S, Israni AK, Danovitch G.. Long-Term survival after kidney transplantation. N Engl J Med. 2021;385(8):729–743. - PubMed
    1. Abbott KC, Cruess DF, Agodoa LY, et al. . Early renal insufficiency and late venous thromboembolism after renal transplantation in the United States. Am J Kidney Dis. 2004;43(1):120–130. - PubMed
    1. Kazory A, Ducloux D.. Acquired hypercoagulable state in renal transplant recipients. Thromb Haemost. 2004;91(4):646–654. - PubMed
    1. Zanazzi M, Poli D, Antonucci E, et al. . Venous thromboembolism in renal transplant recipients: high rate of recurrence. Transplant Proc. 2005;37(6):2493–2494. - PubMed
    1. Biesenbach G, Janko O, Hubmann R, et al. . The incidence of thrombovenous and thromboembolic complications in kidney transplant patients with recurrent glomerulonephritis is dependent on the occurrence of severe proteinuria. Clin Nephrol. 2000;54(5):382–387. - PubMed