Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul;280(7):3249-3258.
doi: 10.1007/s00405-023-07853-w. Epub 2023 Jan 23.

Association between cognition and olfaction-specific parameters in patients with chronic rhinosinusitis

Feifan Chang #  1 , Junsheng Hong #  2 , Fan Yuan  3 , Dawei Wu  4
Affiliations

Association between cognition and olfaction-specific parameters in patients with chronic rhinosinusitis

Feifan Chang et al. Eur Arch Otorhinolaryngol. 2023 Jul.

Abstract

Background: Patients with chronic rhinosinusitis (CRS) have reported significantly cognitive and olfactory dysfunction. This study aimed to explore the relationship between cognitive function and olfaction-specific parameters in patients with CRS.

Methods: A cross-sectional survey method was used to investigate 98 participants, including 75 patients with CRS and 23 healthy controls. Cognitive function and psychophysical olfactory tests were performed. Olfactory cleft endoscopy scale and olfactory cleft computed tomography (CT) scores were obtained. Multivariate logistic regression was used to analyze the risk factors of Mild Cognitive Impairment (MCI) in patients with CRS.

Results: There are significant differences in age, Montreal Cognitive Assessment (MoCA) scores, number of MCI, Lund-Mackay olfactory cleft (LM-OC) score, and blood eosinophil count between CRS with and without olfactory dysfunction groups (all P < 0.05). Total MoCA scores were positively correlated with thresholds-discrimination-identification (TDI) score (r = 0.541, P < 0.001), olfactory threshold (OT) (r = 0.440, P < 0.001), olfactory discrimination (OD) (r = 0.541, P < 0.001), and olfactory identification (OI) (r = 0.382, P = 0.001) scores. Furthermore, total MoCA scores were negatively correlated with LM-OC scores (r = - 0.351, P = 0.002). After adjusting for patient demographics, only the OD score was an independent risk factor for MCI among patients with CRS (odds ratio = 0.792; P = 0.039). The OD scores less than 11.5 were the best predictor of MCI in patients with CRS.

Conclusion: Olfaction-specific clinical parameters were highly correlated with cognitive function in patients with CRS and the OD score was an independent risk factor for MCI in patients with CRS.

Keywords: Anosmia; Chronic rhinosinusitis; Cognitive dysfunction; MoCA; Olfactory dysfunction; Predictor.

PubMed Disclaimer

References

    1. Halawi AM, Smith SS, Chandra RK (2013) Chronic rhinosinusitis: Epidemiology and cost. Allergy Asthma Proc 34(4):328–334. https://doi.org/10.2500/aap.2013.34.3675 - DOI - PubMed
    1. Kohli P, Naik AN, Harruff EE, Nguyen SA, Schlosser RJ, Soler ZM (2017) The prevalence of olfactory dysfunction in chronic rhinosinusitis. Laryngoscope 127(2):309–320. https://doi.org/10.1002/lary.26316 - DOI - PubMed
    1. Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, Damm M, Frasnelli J, Gudziol H, Gupta N, Haehner A, Holbrook E, Hong SC, Hornung D, Huttenbrink KB, Kamel R, Kobayashi M, Konstantinidis I, Landis BN, Leopold DA, Macchi A, Miwa T, Moesges R, Mullol J, Mueller CA, Ottaviano G, Passali GC, Philpott C, Pinto JM, Ramakrishnan VJ, Rombaux P, Roth Y, Schlosser RA, Shu B, Soler G, Stjarne P, Stuck BA, Vodicka J, Welge-Luessen A (2016) Position paper on olfactory dysfunction. Rhinology 56(1):1–30. https://doi.org/10.4193/Rhino16.248 - DOI - PubMed
    1. Harrass S, Yi C, Chen H (2021) Chronic rhinosinusitis and alzheimer’s disease-a possible role for the nasal microbiome in causing neurodegeneration in the elderly. Int J Mol Sci. https://doi.org/10.3390/ijms222011207 - DOI - PubMed - PMC
    1. Soler ZM, Eckert MA, Storck K, Schlosser RJ (2015) Cognitive function in chronic rhinosinusitis: A controlled clinical study. Int Forum Allergy Rhinol 5(11):1010–1017. https://doi.org/10.1002/alr.21581 - DOI - PubMed

LinkOut - more resources