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. 2023 Jan 23;408(1):57.
doi: 10.1007/s00423-023-02799-3.

Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis

Teresa Costa #  1   2 , Jorge Nogueiro #  3   4 , Daniel Ribeiro  3 , Pedro Viegas  3 , Hugo Santos-Sousa  3   4
Affiliations

Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis

Teresa Costa et al. Langenbecks Arch Surg. .

Abstract

Introduction/aim: Serum albumin concentration (COA) and neutrophil-lymphocyte ratio (NLR) could reflect immunological and nutritional status. We aim to evaluate the impact of COA-NLR score on the prognosis of gastric cancer (GC).

Material and methods: We perform a retrospective analysis on a database of 637 GC cases, between January 2010 and December 2017. In 396 patients, the inclusion criteria for this study were met (non-resectional or palliative surgery were excluded). Analytic data was only available in 203 patients. COA-NLR score was defined as follows: COA under 35 g/L and NLR value of 2.585 or higher, score 2; one of these conditions, score 1; and neither, score 0.

Results: In our population (n = 203), 87 patients were classified as score 0, 82 as score 1 and 34 as score 2. COA-NLR score was significantly associated with DFS (HR 1.674; CI 95% 1.115-2.513; p = 0.013) and with OS (HR 2.072; CI 95% 1.531-2.805; p < 0.001). Kaplan-Meier curve analysis (log rank test) revealed that a higher score of COA-NLR predicted a worse OS (p < 0.001) and DFS (p = 0.03). COA-NLR was an independent prognostic factor for OS when adjusted to pStage and age (adjusted HR 1.566; CI 95% 1.145-2.143; p = 0.005).

Conclusions: Preoperative COA-NLR score was significantly associated with worse OS and DFS and, in this way, with worse prognosis on GC patients submitted to curative-intent resectional surgery.

Keywords: Curative-intent resectional surgery; Gastric cancer prognosis; Neutrophil-to-lymphocyte ratio; Serum albumin concentration.

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