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Review
. 2023 Oct;478(10):2221-2240.
doi: 10.1007/s11010-022-04654-3. Epub 2023 Jan 23.

Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate

Divya Sharma  1 , Mit Joshi  2 , Subbu Apparsundaram  1 , Ramesh K Goyal  1 , Bhoomika Patel  3 , Mahaveer Dhobi  4
Affiliations
Review

Solanum nigrum L. in COVID-19 and post-COVID complications: a propitious candidate

Divya Sharma et al. Mol Cell Biochem. 2023 Oct.

Abstract

COVID-19 is caused by severe acute respiratory syndrome coronavirus-2, SARS-CoV-2. COVID-19 has changed the world scenario and caused mortality around the globe. Patients who recovered from COVID-19 have shown neurological, psychological, renal, cardiovascular, pulmonary, and hematological complications. In some patients, complications lasted more than 6 months. However, significantly less attention has been given to post-COVID complications. Currently available drugs are used to tackle the complications, but new interventions must address the problem. Phytochemicals from natural sources have been evaluated in recent times to cure or alleviate COVID-19 symptoms. An edible plant, Solanum nigrum, could be therapeutic in treating COVID-19 as the AYUSH ministry of India prescribes it during the pandemic. S. nigrum demonstrates anti-inflammatory, immunomodulatory, and antiviral action to treat the SARS-CoV-2 infection and its post-complications. Different parts of the plant represent a reduction in proinflammatory cytokines and prevent multi-organ failure by protecting various organs (liver, kidney, heart, neuro, and lung). The review proposes the possible role of the plant S. nigrum in managing the symptoms of COVID-19 and its post-COVID complications based on in silico docking and pharmacological studies. Further systematic and experimental studies are required to validate our hypothesis.

Keywords: COVID-19; Post-COVID complications; SARS-CoV-2 Phytochemicals; Solanum nigrum.

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Conflict of interest statement

The authors declared no conflicts of interest.

Figures

Fig. 1
Fig. 1
Major phytoconstituents of Solanum nigrum L.
Fig. 2
Fig. 2
Long-term complications associated with recovered COVID-19 patients
Fig. 3
Fig. 3
Major targets of Solanum nigrum L. phytochemicals in SARS-CoV-2 infection (in silico and pharmacological)
Fig. 4
Fig. 4
Possible therapeutic role of Solanum nigrum L. in long-term COVID-19 complications
See this image and copyright information in PMC

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