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Review
. 2023 Jul;195(7):4653-4672.
doi: 10.1007/s12010-023-04330-2. Epub 2023 Jan 23.

A Study on Multiple Facets of Apolipoprotein A1 Milano

Farah Maarfi  1 , Mohd Aslam Yusuf  2 , Mohammad Faizan Ali Ahmad  2 , Shahnawaz Rehman  3 , Saloni Aswal  1 , Deepti Dogra  1 , Ajay Singh  4 , Mohd Yasir Khan  5
Affiliations
Review

A Study on Multiple Facets of Apolipoprotein A1 Milano

Farah Maarfi et al. Appl Biochem Biotechnol. 2023 Jul.

Abstract

For several strategies formulated to prevent atherosclerosis, Apolipoprotein A1 Milano (ApoA1M) remains a prime target. ApoA1M has been reported to have greater efficiency in reducing the incidence of coronary artery diseases. Furthermore, recombinant ApoA1M based mimetic peptide exhibits comparatively greater atheroprotective potential, offers a hope in reducing the burden of atherosclerosis in in vivo model system. The aim of this review is to emphasize on some of the observed ApoA1M structural and functional effects that are clinically and therapeutically meaningful that might converge on the basic role of ApoA1M in reducing the chances of glycation assisted ailments in diabetes. We also hypothesize that the nonenzymatic glycation prone arginine amino acid of ApoA1 gets replaced with cysteine residue and the rate of ApoA1 glycation may decrease due to change substitution of amino acid. Therefore, to circumvent the effect of ApoA1M glycation, the related mechanism should be explored at the cellular and functional levels, especially in respective experimental disease model in vivo.

Keywords: Apolipoprotein A1 Milano; Arginine; Atheroprotective; Cardiovascular diseases; Glycation.

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