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. 2023 May 1;118(5):905-908.
doi: 10.14309/ajg.0000000000002137. Epub 2022 Dec 23.

Pentosan Polysulfate-Associated Dysplasia in Patients With Inflammatory Bowel Disease: A Case Series

Jenna Anderson  1 , Spencer Frost  2 , Kian Keyashian  2 , Nir Modiano  1
Affiliations

Pentosan Polysulfate-Associated Dysplasia in Patients With Inflammatory Bowel Disease: A Case Series

Jenna Anderson et al. Am J Gastroenterol. .

Abstract

Introduction: This study evaluates the potential association of pentosan polysulfate (PPS) with inflammatory bowel disease (IBD) or dysplasia.

Methods: We searched electronic medical records to identify patients with IBD using PPS.

Results: Ten of 30 identified patients (33.3%) had colonic dysplasia. Six of them (60%) underwent colectomy for endoscopically unresectable dysplasia. Three (10%) discontinued PPS, each with an apparent benefit.

Discussion: Patients with IBD at 2 institutions who had taken PPS had high rates of colonic dysplasia leading to surgery. Patients who stopped PPS showed improvement in their colitis. PPS may play a causal role in the development of colitis and dysplasia.

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References

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