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Comment
. 2023 Feb;8(2):191-192.
doi: 10.1038/s41564-023-01321-1.

CD8+ T cell depletion does not induce an expansion of viral reservoir in HIV model

No authors listed
Comment

CD8+ T cell depletion does not induce an expansion of viral reservoir in HIV model

No authors listed. Nat Microbiol. 2023 Feb.
No abstract available

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Comment on

  • CD8+ lymphocytes do not impact SIV reservoir establishment under ART.
    Statzu M, Jin W, Fray EJ, Wong AKH, Kumar MR, Ferrer E, Docken SS, Pinkevych M, McBrien JB, Fennessey CM, Keele BF, Liang S, Harper JL, Mutascio S, Franchitti L, Wang H, Cicetti D, Bosinger SE, Carnathan DG, Vanderford TH, Margolis DM, Garcia-Martinez JV, Chahroudi A, Paiardini M, Siliciano J, Davenport MP, Kulpa DA, Siliciano RS, Silvestri G. Statzu M, et al. Nat Microbiol. 2023 Feb;8(2):299-308. doi: 10.1038/s41564-022-01311-9. Epub 2023 Jan 23. Nat Microbiol. 2023. PMID: 36690860 Free PMC article.

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References

    1. Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295–1300 (1997). Study showing the presence of quiescent CD4+ T lymphocytes carrying proviral DNA in people living with HIV on ART. - DOI
    1. Whitney, J. B. et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512, 74–77 (2014). Study showing that the reservoir is seeded rapidly after SIV infection of rhesus macaques and before systemic viraemia. - DOI
    1. Evans, D. T. & Silvestri, G. Non-human primate models in AIDS research. Curr. Opin. HIV AIDS 8, 255–261 (2013). Review describing advances in the use of animal models for HIV and AIDS research.
    1. McBrien, J. B., Kumar, N. A. & Silvestri, G. Mechanism of CD8+ T cell-mediated suppression of HIV/SIV replication. Eur. J. Immunol. 48, 898–914 (2018). Review summarizing the role of CD8+ T cells during natural and ART-treated HIV and SIV infections.
    1. Klatt, N. R. et al. CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells. PLoS Pathog. 6, e1000747 (2010). Study assessing the in vivo effect of CD8 depletion on the lifespan of productively infected cells during chronic SIV infection of rhesus macaques. - DOI

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