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Review
. 2023 Mar;34(1):82-90.
doi: 10.1007/s00399-022-00919-y. Epub 2023 Jan 24.

[How to: clinical use of antiarrhythmic drugs]

[Article in German]
Henrike A K Hillmann  1 , Konstanze Betz  2   3 , Dominik Linz  2   4   5   6 , David Duncker  7
Affiliations
Review

[How to: clinical use of antiarrhythmic drugs]

[Article in German]
Henrike A K Hillmann et al. Herzschrittmacherther Elektrophysiol. 2023 Mar.

Abstract
in English, German

Antiarrhythmic drugs are important for the noninvasive rhythm control therapy of heart rhythm disorders. Antiarrhythmic drugs, which can be categorized into subgroups based on their different effects on ion channels, are clinically used for various types of arrhythmias. Knowledge about these specific electrophysiological effects contributes to a better understanding in order to select the correct drug for each specific arrhythmia. This review summarizes mechanisms, indications, contraindications, and side effects of the different antiarrhythmic drugs and, thus, supports their adequate use in daily clinical routine.

In der Therapie von Herzrhythmusstörungen spielen Antiarrhythmika als nichtinvasive Therapieoption zur Rhythmuskontrolle eine wichtige Rolle. In Abhängigkeit von der Wirkung auf unterschiedliche Ionenkanäle werden die Medikamente in unterschiedliche Gruppen unterteilt – der gezielte Einsatz variiert je nach Art der Herzrhythmusstörung. Wissen über den Wirkmechanismus trägt zum besseren Verständnis für den jeweiligen Einsatz des Antiarrhythmikums bei. Diese Übersichtsarbeit fasst Wirkweise, Indikationen, Kontraindikationen und Nebenwirkungen unterschiedlicher Wirkstoffe zusammen und unterstützt somit die adäquate Anwendung der einzelnen Antiarrhythmika im klinischen Alltag.

Keywords: Atrial fibrillation; Drug therapy; Rhythm control; Supraventricular tachycardias; Ventricular tachycardias.

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