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Review
. 2023 Feb;20(1):44-55.
doi: 10.1007/s11897-023-00587-0. Epub 2023 Jan 24.

Cardiotoxicity of Anti-Cancer Radiation Therapy: a Focus on Heart Failure

Alex Ritter  1 , Cooper Quartermaine  2 , Jovan Pierre-Charles  2 , Suryakumar Balasubramanian  2   3 , Pejman Raeisi-Giglou  2 , Daniel Addison #  2   4 , Eric Miller #  5
Affiliations
Review

Cardiotoxicity of Anti-Cancer Radiation Therapy: a Focus on Heart Failure

Alex Ritter et al. Curr Heart Fail Rep. 2023 Feb.

Abstract

Purpose of review: As the percentage of patients achieving long-term survival following treatment of their cancer grows, it is increasingly important to understand the long-term toxicities of cancer-directed treatment. In this review, we highlight the recent findings regarding radiation-induced cardiotoxicity across multiple disease sites, with a particular focus on heart failure.

Recent findings: Despite its relative lack of study historically, radiation-induced heart failure has now recently been implicated in several studies of breast cancer, lung cancer, esophageal cancer, and lymphoma as a non-trivial potential consequence of thoracic radiotherapy. Data regarding specific cardiac dosimetric endpoints relevant to cardiotoxicity continue to accumulate. Radiation-induced heart failure is a rare but significant toxicity of thoracic radiotherapy, that is likely underreported. Important areas for future focus include understanding the interplay between thoracic radiotherapy and concurrent cardiotoxic systemic therapy as well as development of potential mitigation strategies and novel therapeutics.

Keywords: Cardio-oncology; Cardiotoxicity; Heart failure; Radiation therapy; Thoracic malignancies.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance
    1. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33. https://doi.org/10.3322/caac.21708 . - DOI - PubMed
    1. Sturgeon KM, Deng L, Bluethmann SM, Zhou S, Trifiletti DM, Jiang C, et al. A population-based study of cardiovascular disease mortality risk in US cancer patients. Eur Heart J. 2019;40(48):3889–97. https://doi.org/10.1093/eurheartj/ehz766 . - DOI - PubMed - PMC
    1. Chen L, Ta S, Wu W, Wang C, Zhang Q. Prognostic and added value of echocardiographic strain for prediction of adverse outcomes in patients with locally advanced non-small cell lung cancer after radiotherapy. Ultrasound Med Biol. 2019;45(1):98–107. https://doi.org/10.1016/j.ultrasmedbio.2018.09.012 . - DOI - PubMed
    1. Fourati N, Charfeddine S, Chaffai I, Dhouib F, Farhat L, Boukhris M, et al. Subclinical left ventricle impairment following breast cancer radiotherapy: is there an association between segmental doses and segmental strain dysfunction? Int J Cardiol. 2021;345:130–6. https://doi.org/10.1016/j.ijcard.2021.10.026 . - DOI - PubMed
    1. Taunk NK, Haffty BG, Kostis JB, Goyal S. Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 2015;5:39. https://doi.org/10.3389/fonc.2015.00039 . - DOI - PubMed - PMC

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