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. 2023 Jan;15(1):55-66.
doi: 10.4168/aair.2023.15.1.55.

Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study

Ju Hee Han  1 , Hyun Ji Lee  2 , Hwa Jung Yook  1 , Kyungdo Han  3 , Ji Hyun Lee  1 , Young Min Park  4
Affiliations

Atopic Disorders and Their Risks of Migraine: A Nationwide Population-Based Cohort Study

Ju Hee Han et al. Allergy Asthma Immunol Res. 2023 Jan.

Abstract

Purpose: Migraine is a relatively common neurologic disorder. A possible link between atopic disorders and migraine has been suggested. This study investigated atopic disorders and their risks of migraine in the Korean population.

Methods: From the Korean National Health Insurance Service database, patients aged ≥ 20 years who underwent health screening between January and December of 2009 were enrolled. To evaluate the risk of migraine, Cox proportional hazards regression analyses were performed.

Results: In multivariable analysis, the atopic dermatitis group (adjusted hazard ratio [aHR], 1.28; 95% confidence interval [CI], 1.23-1.33), asthma group (aHR, 1.32; 95% CI, 1.30-1.34) and allergic rhinitis group (aHR, 1.45; 95% CI, 1.44-1.46) had significantly increased risks of migraine compared to their respective control groups (P < 0.001). The patients with 1 (aHR, 1.43; 95% CI, 1.42-1.44), 2 (aHR, 1.50; 95% CI, 1.47-1.53), and 3 (aHR, 1.64; 95% CI, 1.43-1.88) atopic disorders had significantly increased risks of migraine compared to the control group (P < 0.001).

Conclusions: Our results demonstrate that patients with atopic disorders may have increased risk of migraine and that the larger the number of concomitant atopic disorders, the higher the risk of migraine.

Keywords: Epidemiology; allergic rhinitis; asthma; atopic dermatitis; migraine.

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Conflict of interest statement

There are no financial or other issues that might lead to conflict of interest.

Figures

Figure
Figure. (A) Flowchart of enrolled subjects. (B) Distribution of the study population enrolled in the study.
See this image and copyright information in PMC

References

    1. Ravnborg N, Ambikaibalan D, Agnihotri G, Price S, Rastogi S, Patel KR, et al. Prevalence of asthma in patients with atopic dermatitis: a systematic review and meta-analysis. J Am Acad Dermatol. 2021;84:471–478. - PubMed
    1. Oliveira C, Torres T. More than skin deep: the systemic nature of atopic dermatitis. Eur J Dermatol. 2019;29:250–258. - PubMed
    1. Silverberg JI. Comorbidities and the impact of atopic dermatitis. Ann Allergy Asthma Immunol. 2019;123:144–151. - PubMed
    1. Bellanti JA, Settipane RA. The atopic disorders and atopy … “strange diseases” now better defined! Allergy Asthma Proc. 2017;38:241–242. - PMC - PubMed
    1. Ashina M. Migraine. N Engl J Med. 2020;383:1866–1876. - PubMed