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. 2023 Jan 24;22(1):11.
doi: 10.1186/s12944-023-01775-6.

Relationship of liver fat content with systemic metabolism and chronic complications in patients with type 2 diabetes mellitus

Weiwei Ren #  1 , Yunlu Feng #  2 , Youzhen Feng  3 , Jiaying Li  1 , Chuangbiao Zhang  1 , Lie Feng  1 , Lijuan Cui  4 , Jianmin Ran  5
Affiliations

Relationship of liver fat content with systemic metabolism and chronic complications in patients with type 2 diabetes mellitus

Weiwei Ren et al. Lipids Health Dis. .

Abstract

Objective: This study investigated the correlation of liver fat content (LFC) with metabolic characteristics and its association with chronic complications in type 2 diabetes mellitus (T2DM) patients.

Methods: Eighty-one prospectively enrolled T2DM patients were divided into non-alcoholic fatty liver disease (NAFLD) group and the non-NAFLD group according to the presence of NAFL complications. LFC was determined by MRI IDEAL-IQ Sequence, and patients were divided into 4 groups according to LFC by quartile method. Basic information, metabolic indexes, and occurrence of chronic complications in different groups were analyzed and compared.

Results: BMI, SBP, DBP, TG, ALT, AST, GGT, UA, HbA1c, FCP, 2 h CP, HOMA-IR, and HOMA-IS in the NAFLD group were significantly higher than the non-NAFLD group (P < 0.05). The incidences of chronic complications in the NAFLD group were higher than in the non-NAFLD group but not statistically significant (P > 0.05). BMI, SBP, DBP, TC, TG, ALT, AST, FCP, 2 h CP, HOMA-IR, and HOMA-IS showed significant differences between the patients with different LFC, and these indexes were significantly higher in patients with higher LFC than those with lower LFC (P < 0.05). Moreover, diabetes duration, TC, HOMA-IR, and LFC were the risk factors for ASCVD complications, while diabetes duration, TG, and LDL-C were risk factors for DN complications. Also, diabetes duration and SBP were risk factors for both DR and DPN complications in T2DM patients (P < 0.05).

Conclusion: LFC is positively correlated with the severity of the systemic metabolic disorder and chronic complications in T2DM patients.

Keywords: Chronic complications; IDEAL-IQ; Liver fat content; Metabolic disorder; Type 2 diabetes mellitus.

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Conflict of interest statement

All authors declare that there are no conflicts of interest.

Figures

Fig. 1
Fig. 1
Location of the region of interest (ROI) in MRI IDEAL-IQ Sequence. A In-phase image of the region of interest. B Out-of-phase image of the region of interest
See this image and copyright information in PMC

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