Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan-Feb;39(1):172-176.
doi: 10.12669/pjms.39.1.6627.

The effect of low-molecular-weight heparin combined with amikacin on the coagulation function and bacterial clearance in the treatment of patients with severe senile pneumonia

Aihong Luo  1 , Ya Liu  2
Affiliations

The effect of low-molecular-weight heparin combined with amikacin on the coagulation function and bacterial clearance in the treatment of patients with severe senile pneumonia

Aihong Luo et al. Pak J Med Sci. 2023 Jan-Feb.

Abstract

Objective: To analyze the effect of the combined low-molecular-weight heparin (LMWH) and amikacin treatment on the bacterial clearance and changes in coagulation function in patients with severe pneumonia (SP).

Methods: A single-center retrospective observational study was conducted. Medical records of 526 elderly patients with SP admitted to the ICU Department of Shandong Provincial Third Hospital from February, 2018 to December, 2021 were reviewed and 342 patients were identified. The patients were divided into two groups according to the treatment records: the study group (175 patients received LMWH combined with amikacin) and the control group (167 patients received amikacin). Changes in coagulation indexes before and after the treatment, as well as bacterial clearance rate and clinical efficacy after the treatment were compared between the two groups.

Results: There was no significant difference in prothrombin time (PT), D-Dimer (D-D), antithrombin III (AT-III) and fibrinogen (FIB) levels between the two groups before the treatment (P>0.05). After the treatment, levels of PT, D-D and FIB in the two groups decreased and the level of AT-III increased(P<0.05). Levels of PT, D-D and FIB in the study group were lower, and the level of AT-III was higher (P<0.05) that n in the control group. Bacterial clearance rate in the study group was (86.19%), higher than that in the control group (72.25%) (P<0.05). The total clinical effective rate of the study group (93.14%) was significantly higher than that of the control group (79.04%) (P<0.05).

Conclusions: Combining LMWH with amikacin in the treatment of elderly SP patients can improve the coagulation function and bacterial clearance, can promote the recovery of patients and has a good clinical application value.

Keywords: Amikacin; Bacterial clearance; Low molecular weight heparin; Severe pneumonia.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Rukavishnikova SA, Akhmedov TA, Pushkin AS, Saginbaev UR, Piskunov DP, Volchkova EV. Features of the coefficient of variation of hematological indicators in persons of middle, elderly and senile age with pneumonia. Adv Gerontol Uspekhi Gerontol. 2021;34(1):102–106. - PubMed
    1. Velavan TP, Meyer CG. Mild versus severe COVID-19:Laboratory markers. Int J Infect Dis. 2020;95:304–307. doi:10.1016/j.ijid.2020.04.061. - PMC - PubMed
    1. Niederman MS, Alder J, Bassetti M, Boateng F, Cao B, Corkery K, et al. Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE):a double-blind, randomised, placebo-controlled, phase 3, superiority trial. Lancet Infect Dis. 2020;20(3):330–340. doi:10.1016/S1473-3099(19)30574-2. - PubMed
    1. Shehzadi N, Hussain K, Khan MT, Salman M, Islam M. Evaluation of dynamics of derivatization and development of RP-HPLC method for the determination of amikacin sulphate. Pak J Pharm Sci. 2017;30(5):1767–1777. - PubMed
    1. Sharma L, Wu J, Patel V, Sitapara R, Rao NV, Kennedy TP, et al. Partially-desulfated heparin improves survival in Pseudomonas pneumonia by enhancing bacterial clearance and ameliorating lung injury. J Immunotoxicol. 2014;11(3):260–267. doi:10.3109/1547691X.2013.839587. - PubMed

LinkOut - more resources