Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan-Feb;39(1):23-27.
doi: 10.12669/pjms.39.1.6849.

Comparison of ultrasound-guided serratus anterior plane block and thoracic paravertebral block in postoperative analgesia and inflammation control in patients undergoing upper abdominal surgery

Zhiming Cai  1 , Ruiqun Xie  2 , Ting Xu  3 , Changlu Huang  4
Affiliations

Comparison of ultrasound-guided serratus anterior plane block and thoracic paravertebral block in postoperative analgesia and inflammation control in patients undergoing upper abdominal surgery

Zhiming Cai et al. Pak J Med Sci. 2023 Jan-Feb.

Abstract

Objective: To compare the effects of ultrasound-guided serratus anterior plane block (SAPB) and thoracic paravertebral block (TPVB) on postoperative analgesia and inflammation control in patients undergoing upper abdominal surgery.

Methods: This is a retrospective observational study. The records of patients who underwent upper abdominal surgery in our hospital from June 2019 to January 2021 were selected and retrospectively divided into two groups based on the analgesia method. Fifty-nine patients received ultrasound-guided SAPB analgesia (SAPB-group) and 55 patients received ultrasound-guided TPVB analgesia (TPVB-Group). Patients were matched for age, gender and body-mass index (BMI). The visual analogue scale (VAS) scores of pain at two hours(T1), six hours (T2), 12 hours (T3), 24 hours (T4) and 48 hours (T5) after the operation were compared between the two groups. The levels of interleukin-6 (IL-6), interleukin-10(IL-10) and tumor necrosis factor-α (TNF-α) at the completion of surgery (T0) and T4 were compared between the two groups.

Results: The duration of block in SAPB-group was higher than that in TPVB-group (P<0.05). VAS scores of SAPB-groups were significantly lower than those of TPVB-group at all-time points (P<0.05) except at rest 48 hour after the procedure. The levels of IL-6, IL-10 and TNF-α at 24 hours after the operation in both groups were significantly higher than immediately at the end of the operation (P<0.05). Levels of IL-6 and TNF-α 24 hours after the operation were significantly lower in the SAPB-group than in the TPVB-group (P<0.05), while the levels of IL-10 24 hours after the operation were significantly higher in the SAPB-group (P<0.05).

Conclusions: SAPB block under ultrasound guidance for patients undergoing upper abdominal surgery has good anesthetic and analgesic effect and can significantly improve the level of postoperative inflammation.

Keywords: Analgesia; Inflammatory response; Thoracic paravertebral block; Ultrasound-guided serratus anterior plane block; Upper abdominal surgery.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None.

Similar articles

See all similar articles

References

    1. Mulier JP. Is opioid-free general anesthesia for breast and gynecological surgery a viable option? Curr Opin Anaesthesiol. 2019;32(3):257–262. doi:10.1097/ACO.0000000000000716. - PubMed
    1. Zhang J, Zhao H, Lv L, Yuan J, Sun Y. Uniportal thoracoscopic pulmonary lobectomy in the treatment of Lung Cancer. Pak J Med Sci. 2020;36(2):182–186. doi:10.12669/pjms.36.2.793. - PMC - PubMed
    1. Wang L, Wu LX, Han Z, Ma WH, Geng ZH. Effect of flurbiprofen axetil combined with “Cocktail”therapy on opioid dosage in patients after total knee arthroplasty. Pak J Med Sci. 2022;38((3Part-I)):724–729. doi:10.12669/pjms.38.3.4735. - PMC - PubMed
    1. Mariano ER, Marshall ZJ, Urman RD, Kaye AD. Ultrasound and its evolution in perioperative regional anesthesia and analgesia. Best Pract Res Clin Anaesthesiol. 2014;28(1):29–39. doi:10.1016/j.bpa.2013.11.001. - PubMed
    1. Marhofer P, Willschke H, Kettner S. Current concepts and future trends in ultrasound-guided regional anesthesia. Curr Opin Anaesthesiol. 2010;23(5):632–636. doi:10.1097/ACO.0b013e32833e2891. - PubMed

LinkOut - more resources