Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations
- PMID: 36694887
- PMCID: PMC9835814
- DOI: 10.17925/EE.2022.18.2.133
Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations
Abstract
Male hypogonadism affects 10-30% of the male population and is often under-recognized and under-treated. Different replacement formulations exist, each with specific benefits and limitations. These replacements include gels, patches and short- and long-acting injectables. JATENZO® (oral testosterone undecanoate; Clarus Therapeutics Inc., Northbrook, IL, US) is the first oral formulation of testosterone approved by the US Food and Drug Administration. TLANDO® (oral testosterone undecanoate; Lipocine Inc., Salt Lake City, UT, US), another oral testosterone formulation, has also recently been approved by the US Food and Drug Administration. Based on unique chemistry using a self-emulsifying drug delivery system and lymphatic absorption, JATENZO and TLANDO address some of the limitations of other dosing routes while providing a safe option without evidence of liver dysfunction. This review discusses various testosterone treatment options, focusing on the role and pharmacokinetics of the new oral formulations.
Keywords: JATENZO; TLANDO; male hypogonadism; oral testosterone replacement; self-emulsifying drug delivery systems; testosterone replacement therapy; testosterone undecanoate.
© Touch Medical Media 2022.
Conflict of interest statement
Disclosure: Salman Z Bhat and Adrian S Dobs have no financial or non-financial relationships or activities to declare in relation to this article.
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