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. 2022 Dec;27(50):2200899.
doi: 10.2807/1560-7917.ES.2022.27.50.2200899.

Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022

Béatrice Berçot  1   2   3 , François Caméléna  1   2   3 , Manel Mérimèche  1   2   3 , Susanne Jacobsson  4 , Ghalia Sbaa  1   2 , Mary Mainardis  1   2 , Cyrille Valin  5 , Jean-Michel Molina  6   7 , Cécile Bébéar  8 , Emilie Chazelle  9 , Florence Lot  9 , Daniel Golparian  4 , Magnus Unemo  10   4
Affiliations

Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022

Béatrice Berçot et al. Euro Surveill. 2022 Dec.

Abstract

We report a ceftriaxone-resistant, multidrug-resistant urogenital gonorrhoea case in a heterosexual woman in France, June 2022. The woman was successfully treated with azithromycin 2 g. She had unprotected sex with her regular partner, who developed urethritis following travel to Vietnam and Switzerland. Whole genome sequencing of the gonococcal isolate (F92) identified MLST ST1901, NG-STAR CC-199, and the novel mosaic penA-237.001, which caused ceftriaxone resistance. penA-237.001 is 98.7% identical to penA-60.001, reported in various ceftriaxone-resistant strains, including the internationally spreading FC428 clone.

Keywords: Neisseria gonorrhoeae; antimicrobial resistance; ceftriaxone; multidrug-resistant N. gonorrhoeae (MDR-NG); travel.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Core phylogenomics of publicly available Neisseria gonorrhoeae genome sequences (n = 36,310) showing the ceftriaxone-resistant, multidrug-resistant F92 gonococcal isolate from France and other published ceftriaxone-resistant gonococcal strains (n = 28), June 2022
Figure 2
Figure 2
Phylogeny of the most closely related publicly available Neisseria gonorrhoeae genome sequences (n = 52) and the ceftriaxone-resistant, multidrug-resistant F92 gonococcal isolate from France, June 2022
See this image and copyright information in PMC

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