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. 2022 Dec;27(50):2200926.
doi: 10.2807/1560-7917.ES.2022.27.50.2200926.

Increase in NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae in Germany associated with the war in Ukraine, 2022

Mirco Sandfort  1 , Jörg B Hans  2 , Martin A Fischer  3 , Felix Reichert  1 , Martina Cremanns  2 , Jessica Eisfeld  2 , Yvonne Pfeifer  3 , Annika Heck  1 , Tim Eckmanns  1 , Guido Werner  3 , Sören Gatermann  2 , Sebastian Haller  1 , Niels Pfennigwerth  2
Affiliations

Increase in NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae in Germany associated with the war in Ukraine, 2022

Mirco Sandfort et al. Euro Surveill. 2022 Dec.

Abstract

In 2022, German surveillance systems observed rapidly increasing numbers of NDM-1- and NDM-1/OXA-48-producing Klebsiella pneumoniae, which may in part reflect recurring pre-pandemic trends. Among these cases, however, a presence in Ukraine before diagnosis was frequently reported. Whole genome sequencing of 200 isolates showed a high prevalence of sequence types ST147, ST307, ST395 and ST23, including clusters corresponding to clonal dissemination and suggesting onward transmission in Germany. Screening and isolation of patients from Ukraine may help avoid onward transmission.

Keywords: Germany; Klebsiella pneumoniae; NDM-1; NDM-1/OXA-48; Ukraine; antimicrobial resistance; carbapenemase-producing Enterobacterales; genomic surveillance.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Notifications of NDM-producing Klebsiella pneumoniae and other carbapenemase-producing Enterobacterales and carbapenemase detections for multidrug-resistant Gram-negative bacteria, Germany, 2022
Figure 2
Figure 2
Phylogenetic tree of NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae isolates, Germany, January–September 2022 (n = 200)
Figure 3
Figure 3
Phylogenetic tree and heatmap based on pairwise single nucleotide variant (cgSNV) differences between isolates of Klebsiella pneumoniae ST147, Germany, January–September 2022 (n = 88)
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References

    1. Schranz M, Ullrich A, Rexroth U, Hamouda O, Schaade L, Diercke M, et al. Die Auswirkungen der COVID-19-Pandemie und assoziierter Public-Health-Maßnahmen auf andere meldepflichtige Infektionskrankheiten in Deutschland (MW 1/2016 – 32/2020). [The effects of the COVID-19 pandemic and associated public health measures on other notifiable infectious diseases in Germany]. Epid Bull. 2021;7:3-7. German. 10.25646/8011 - DOI
    1. Reuss A, Klingeberg A, Schmidt N, Eckmanns T, Zacher B. Einfluss der COVID-19-Pandemie auf die Anzahl der gemäß IfSG meldepflichtigen Nachweise von Erregern mit Antibiotikaresistenzen und C. difficile-Infektionen. [Impact of the COVID-19 pandemic on the number of confirmations of pathogens with antibiotic resistance and C. difficile infections notifiable under the Infection Protection Act]. Epid Bull. 2021;7:8-11. German. 10.25646/8026 - DOI
    1. Pfennigwerth N. Schauer J. Bericht des Nationalen Referenzzentrums für gramnegative Krankenhauserreger – Zeitraum 1. Januar 2021 bis 31. Dezember 2021. [Report of the National Reference Centre for Gram-negative hospital pathogens - period 1 January 2021 to 31 December 2021]. Epid Bull. 2022;19:3-9. German. Available from: http://edoc.rki.de/176904/9709
    1. Kondratiuk V, Jones BT, Kovalchuk V, Kovalenko I, Ganiuk V, Kondratiuk O, et al. Phenotypic and genotypic characterization of antibiotic resistance in military hospital-associated bacteria from war injuries in the Eastern Ukraine conflict between 2014 and 2020. J Hosp Infect. 2021;112:69-76. 10.1016/j.jhin.2021.03.020 - DOI - PubMed
    1. Dietze N, Trawinski H, Schönherr SG, Lippmann N, Ranft D, Fichtner F, et al. Infektionsmedizinische und chirurgische Herausforderungen durch Carbapenem-resistente bakterielle Erreger bei der Versorgung Kriegsverletzter aus der Ukraine. [Challenges in infection medicine and surgery caused by carbapenem-resistant bacterial pathogens in the care for war casualties from Ukraine]. Epid Bull. 2022;36:3-10. German. Available from: http://edoc.rki.de/176904/10214

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