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. 2023 Jun;38(6):817-824.
doi: 10.1007/s00380-023-02235-y. Epub 2023 Jan 25.

Risk of recurrent stroke and mortality after cryptogenic stroke in diabetic patients

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Risk of recurrent stroke and mortality after cryptogenic stroke in diabetic patients

Alberto Vera et al. Heart Vessels. 2023 Jun.

Abstract

Background: Diabetes mellitus is a highly prevalent and growing chronic disease that is associated with increased risk of recurrence among several stroke subtypes. However, evidence on the prognostic role of diabetes in the setting of cryptogenic stroke (CS) remains scarce.

Methods: From April 2019 to November 2021, we recruited prospectively 78 consecutive patients with CS. Patients were classified according to the presence of diabetes. Main outcome was the composite of stroke recurrence and death. Secondary outcome was stroke recurrence.

Results: Mean age of the cohort was 78 ± 7.7 years and 18 patients (23%) had diabetes. After a median clinical follow-up of 23 months the incidence of stroke recurrence and mortality [HR 5.8 (95% CI 1.9-19), p = 0.002] and the incidence of stroke recurrence [HR 16.6 (95% CI 1.8-149), p = 0.012], were higher in patients with diabetes. After adjusting for potential confounders diabetes was identified as an independent predictor of stroke recurrence and death in patients with CS [HR 33.8 (95% CI 2.1-551), p = 0.013]. Other independent predictors of stroke recurrence and mortality were hypertension [HR 31.4 (95% CI 1.8-550), p = 0.018], NTproBNP [HR 1.002 (95% CI 1.001-1.004), p = 0.013] and chronic kidney disease (CKD) [HR 27.4 (95% CI 1.4-549) p = 0.03]. Furthermore, diabetes was an independent predictor of stroke recurrence [HR 103 (95% CI 1.3-8261), p = 0.038].

Conclusion: Diabetic patients with CS are at higher risk of stroke recurrence and death. Hypertension CKD and NTproBNP are also independent predictors of stroke recurrence and death after CS.

Keywords: Chronic kidney disease; Cryptogenic stroke; Diabetes; NTproBNP; Stroke recurrence.

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References

    1. Zhang L, Li X, Wolfe CDA, O’Connell MDL, Wang Y (2021) Diabetes as an independent risk factor for stroke recurrence in ischemic stroke patients: an updated meta-analysis. Neuroepidemiology 55(6):427–435 - DOI - PubMed
    1. Kim JS, Nah HW, Park SM, Kim SK, Cho KH, Lee J, Lee YS, Kim J, Ha SW, Kim EG, Kim DE, Kang DW, Kwon SU, Yu KH, Lee BC (2012) Risk factors and stroke mechanisms in atherosclerotic stroke. Intracranial compared with extracranial and anterior compared with posterior circulation disease. Stroke 43(12):3313–3318 - DOI - PubMed
    1. Regenhardt RW, Das AS, Ohtomo R, Lo EH, Ayata C, Gurol ME (2019) Pathophysiology of lacunar stroke: history’s mysteries and modern interpretations. J Stroke Cerebrovasc Dis 28(8):2079–2097 - DOI - PubMed - PMC
    1. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL (2019) Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 50:e344–e418 - DOI - PubMed
    1. Guzik A, Bushnell C (2017) Stroke epidemiology and risk factor management. Continuum (Minneap Minn) 23:15–39 - PubMed

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