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Comment
. 2023 Jan 25;21(1):e3001997.
doi: 10.1371/journal.pbio.3001997. eCollection 2023 Jan.

A rising tide of parasite transcriptomics propels pathogen biology

Manoj T Duraisingh  1 , Marc-Jan Gubbels  2 , Kourosh Zarringhalam  3   4
Affiliations
Comment

A rising tide of parasite transcriptomics propels pathogen biology

Manoj T Duraisingh et al. PLoS Biol. .

Abstract

Twenty years ago, the first transcriptome of the intraerythrocytic developmental cycle of the malaria parasite Plasmodium falciparum was published in PLOS Biology. Since then, transcriptomics studies have transformed the study of parasite biology.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The evolution of parasite transcriptomics.
The advent of the expression microarray was a transformative event that for the first time revealed dynamic, genome-wide expression changes. Over time, in the postgenomic era, this has become more refined in spatiotemporal resolution. The next wave of systems biology requires new computational tools that are expected to reveal new aspects of parasite biology for translation. Adapted from [1]. AI, artificial intelligence; EST, expressed sequence tag; ML, machine learning; qRT-PCR, quantitative reverse transcription PCR; ribo-seq, ribosome sequencing; RNA-Seq, RNA sequencing; SAGE, Serial Analysis of Gene Expression; scRNA-seq, single-cell RNA sequencing; SNV, single-nucleotide variation; UMAP, Uniform Manifold Approximation and Projection.
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Comment on

References

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