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Review
. 2023 Jan;9(1):124-138.
doi: 10.1016/j.jacep.2022.09.017. Epub 2022 Nov 30.

Cardiac Repolarization in Health and Disease

Christian Krijger Juárez  1 , Ahmad S Amin  2 , Joost A Offerhaus  1 , Connie R Bezzina  1 , Bastiaan J Boukens  3
Affiliations
Free article
Review

Cardiac Repolarization in Health and Disease

Christian Krijger Juárez et al. JACC Clin Electrophysiol. 2023 Jan.
Free article

Abstract

Abnormal cardiac repolarization is at the basis of life-threatening arrhythmias in various congenital and acquired cardiac diseases. Dysfunction of ion channels involved in repolarization at the cellular level are often the underlying cause of the repolarization abnormality. The expression pattern of the gene encoding the affected ion channel dictates its impact on the shape of the T-wave and duration of the QT interval, thereby setting the stage for both the occurrence of the trigger and the substrate for maintenance of the arrhythmia. Here we discuss how research into the genetic and electrophysiological basis of repolarization has provided us with insights into cardiac repolarization in health and disease and how this in turn may provide the basis for future improved patient-specific management.

Keywords: genome-wide association studies; long-QT syndrome; repolarization; short-QT syndrome.

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Conflict of interest statement

Funding Support and Author Disclosures Dr Bezzina is supported by the Dutch Heart Foundation (CVON Predict2 project), the Netherlands Organization for Scientific Research (VICI fellowship, 016.150.610), Fondation Leducq (17CVD02), Horstingstuit Foundation, and the EJP-RD LQTS-NEXT project (ZonMW project 40-46300-98-19009). Dr Juárez is supported by the MD-PHD scholarship in the Amsterdam University Medical Centers graduate school. Dr Offerhaus is supported by a PHD scholarship in the AUMC graduate school. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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