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. 2023 Mar;41(3):286-288.
doi: 10.1016/j.tibtech.2023.01.006. Epub 2023 Jan 24.

Engineering biology for sustainable 1,4-butanediol synthesis

Connor L Trotter  1 , Gautham S Babu  1 , Stephen Wallace  2
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Free article

Engineering biology for sustainable 1,4-butanediol synthesis

Connor L Trotter et al. Trends Biotechnol. 2023 Mar.
Free article

Abstract

Over the past decade, numerous approaches have been taken to replace unsustainable chemical syntheses with green biosynthetic alternatives. In a landmark paper, Yim et al. utilised an in silico-to-in vivo workflow to enable the high-level bioproduction of the unnatural small molecule 1,4-butanediol in the bacterium Escherichia coli.

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Declaration of interests No interests are declared.

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