Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar;33(3):258-261.
doi: 10.1038/s41422-023-00781-8. Epub 2023 Jan 25.

Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection

Bo Gao #  1   2 , Liheng He #  1 , Yujie Bao #  3 , Yingying Chen #  1   4   5 , Guanzhu Lu  3 , Yu Zhang  6 , Yingjie Xu  6 , Bing Su  1   2   7 , Jie Xu  8 , Ying Wang  9   10   11   12 , Leng-Siew Yeap  13   14
Affiliations

Repeated vaccination of inactivated SARS-CoV-2 vaccine dampens neutralizing antibodies against Omicron variants in breakthrough infection

Bo Gao et al. Cell Res. 2023 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Comparisons of pseudovirus neutralizing titers in BA.2-infected individuals with different vaccination backgrounds.
a The schematic diagram shows the number of unvaccinated, 2-dose and 3-dose vaccinated individuals prior to BA.2 infection or breakthrough infection. b The stacked bars represent the proportion of all BA.2-infected patients, presenting with the indicated clinical symptoms. The numbers shown in the bar and above the bar represent the percentages of people with the indicated clinical symptoms and the total number of people in each vaccination group, respectively. Two-tailed χ2 tests were performed in b. ****P < 0.0001; ns, not significant. c The percentages of individuals with the indicated pVNT50 values in SARS-CoV-2, BA.2, BA.4 and BA.5 pseudovirus neutralization assays are displayed. d Box plots show the pVNT50 values of samples that are above the detection limit. Each black dot represents a sample. The whiskers show the minimum and maximum pVNT50 titers. The line in the box represents median. The GMTs of each group are indicated in numbers on the top of each box plot. Black dotted line represents the detection threshold. e The ratio of the GMTs of the 2-dose or 3-dose group over the unvaccinated group is shown. Orange numbers indicate the ratio of the GMT of the 3-dose group over the unvaccinated group. Green numbers indicate the ratio of the GMT of the 2-dose group over the unvaccinated group. Statistical analysis was performed using unpaired two-tailed Mann-Whitney tests. *P < 0.05; ns, not significant.
See this image and copyright information in PMC

References

    1. Karim SSA, et al. Lancet. 2021;398:2126–2128. doi: 10.1016/S0140-6736(21)02758-6. - DOI - PMC - PubMed
    1. Wang Q, et al. Nature. 2022;608:603–608. doi: 10.1038/s41586-022-05053-w. - DOI - PMC - PubMed
    1. Cao Y, et al. Nature. 2022;602:657–663. doi: 10.1038/s41586-021-04385-3. - DOI - PMC - PubMed
    1. Yu X, et al. Cell Discov. 2022;8:4. doi: 10.1038/s41421-022-00375-5. - DOI - PMC - PubMed
    1. Henry C, et al. Trends Immunol. 2018;39:70–79. doi: 10.1016/j.it.2017.08.003. - DOI - PMC - PubMed

Publication types

Supplementary concepts