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Review
. 2023 Jan 25;23(1):11.
doi: 10.1186/s12935-023-02854-5.

Tumor microenvironment in ovarian cancer peritoneal metastasis

Shuangshuang Mei  1 , Xing Chen  1 , Kai Wang  1 , Yuxin Chen  2
Affiliations
Review

Tumor microenvironment in ovarian cancer peritoneal metastasis

Shuangshuang Mei et al. Cancer Cell Int. .

Abstract

Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum is one of the most common metastatic sites in ovarian cancer, involving large amounts of ascites. However, its mechanism is unclear. The peritoneal microenvironment composed of peritoneal effusion and peritoneum creates favorable conditions for ovarian cancer progression and metastasis. Here, we reviewed the peritoneal metastasis patterns and molecular mechanisms of ovarian cancer, as well as major components of the peritoneal microenvironment, peritoneal effusion, and immune microenvironment, and investigated the relationship between the peritoneal microenvironment and ovarian cancer metastasis.

Keywords: Metastasis; Ovarian cancer; Tumor microenvironment.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Different stages of ovarian cancer
Fig. 2
Fig. 2
Two main pathways of peritoneal metastasis in ovarian cancer
See this image and copyright information in PMC

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